PMID: 8939720Oct 1, 1996Paper

Retinoid receptors in transcriptional regulation

Current Opinion in Genetics & Development
S Minucci, K Ozato

Abstract

Our understanding of the mechanism of action of retinoids has been greatly expanded by a series of recent findings. First, the three-dimensional structure of the ligand-binding domain of two retinoid receptors has been solved and suggests that ligand binding induces marked allosteric changes. Second, several co-factors interacting with the receptors have been cloned, some of which are capable of regulating the function of receptors. Third, the advent of synthetic retinoids helped define the activities of the receptors. Fourth, the study of the in vivo receptor-DNA interactions has revealed a previously unrecognized role of the ligand in regulating the stability of receptor-DNA complexes. These advances have revealed complex molecular interactions operating at multiple levels, opening new avenues of research for addressing their mechanisms.

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Citations

Oct 4, 2006·Nature Reviews. Drug Discovery·Peter ImmingAchim Meyer
Jun 17, 1998·Genes & Development·J C BlancoK Ozato
Sep 28, 2000·Biochemical and Biophysical Research Communications·L WangR H Lenox
Aug 14, 2001·Biochemical and Biophysical Research Communications·A C GidlöfA Sirsjö
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·S MinucciK Ozato
Jun 8, 2014·Best Practice & Research. Clinical Haematology·Francesco Lo-Coco, Syed Khizer Hasan
Jul 5, 2005·Toxicology Letters·Hidekuni Inadera, Akiko Shimomura
Apr 23, 2004·The EMBO Journal·Annemieke IJpenbergBéatrice Desvergne
May 11, 2001·Molecular Carcinogenesis·J Dufner-BeattieA Thorburn
Jun 20, 1998·The Journal of Biological Chemistry·P LefebvreP Formstecher
Jan 6, 2001·Molecular Endocrinology·F D Urnov, A P Wolffe
Oct 19, 2001·Oncogene·M AlcalayP G Pelicci
Apr 25, 2000·Biochemical and Biophysical Research Communications·A SirsjöG K Hansson
Oct 29, 1997·Molecular and Cellular Biology·N BhattacharyyaK Ozato

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