PMID: 11319133Apr 25, 2001Paper

Retinoid receptors involved in the effects of retinoic acid on rat testis development

Biology of Reproduction
Gabriel LiveraRené Habert

Abstract

We have previously shown that retinoic acid (RA) is able to act on the development of Leydig, Sertoli, and germ cells in the testis in culture (Livera et al., Biol Reprod 2000; 62:1303-1314). To identify which receptors mediate these effects, we have now added selective agonists and antagonists of retinoic acid receptors (RARs) or retinoid X receptors (RXRs) in the same organotypic culture system. The RAR alpha agonist mimicked most of the effects of RA on the cultured fetal or neonatal testis, whereas the RAR beta, gamma, and pan RXR agonists did not. The RAR alpha agonist decreased the testosterone production, the number of gonocytes, and the cAMP response to FSH of fetal testis explanted at 14.5 days postconception (dpc). The RAR alpha agonist disorganized the cords of the 14.5-dpc cultured testis and increased the cord diameter in cultured 3-days-postpartum (dpp) testis in the same way as RA. All these RA effects could be reversed by an RAR alpha antagonist and were unchanged by an RAR beta/gamma antagonist. The RAR beta agonist, however, increased Sertoli cell proliferation in the 3-dpp testis in the same way as RA, and this effect was blocked by an RAR beta antagonist. The RAR gamma and the pan RXR agonists had no selecti...Continue Reading

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Citations

Mar 8, 2006·Cell and Tissue Research·Gabriel LiveraRené Habert
Jan 21, 2012·Biology of Reproduction·Kohei OhtaYukiko Yamazaki
Nov 15, 2011·Biology of Reproduction·Michael D GriswoldPeter Koopman
Apr 10, 2012·Toxicology and Applied Pharmacology·V MuczynskiV Rouiller-Fabre
Dec 29, 2009·Molecular and Cellular Endocrinology·Katherine A Ewen, Peter Koopman
Mar 9, 2007·Molecular and Cellular Neurosciences·Jing Yang, Joseph E O'Tousa
Feb 17, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Pedro M AponteAns M M van Pelt
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Martine Culty
Feb 1, 2003·Andrologia·V Rouiller-FabreR Habert
Jun 1, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Abdelali LehraikiChristine Levacher
Feb 26, 2004·The Journal of Biological Chemistry·Guie GuJoseph E O'Tousa
Jul 16, 2004·Journal of Cellular Physiology·G RicciM Galdieri
Nov 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel J SpadeKim Boekelheide
Jan 25, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Raffaella ComitatoAnna Cardone
Nov 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Zengli YuYong Li
Sep 24, 2005·Molecular and Cellular Biochemistry·Daniel Pens GelainJosé Cláudio Fonseca Moreira
Sep 29, 2019·Biomolecules·Laura BelluttiGabriel Livera
Oct 18, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daniel J SpadeKim Boekelheide
Jan 8, 2021·Reproductive Biology and Endocrinology : RB&E·Maryam KhanehzadSeyed Mehdi Nourashrafeddin
Dec 10, 2020·Journal of Toxicology·Nadezhda V TyshkoValentin M Zhminchenko

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