Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice

Neuron
Agnieszka KrzyzosiakW Krezel

Abstract

Abnormal signaling by retinoids or n-3 polyunsaturated fatty acids has been implicated in clinical depression. The converging point in activities of these two classes of molecules is transcriptional activation of retinoid X receptors (Rxr). We show here that ablation of Rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling. While abnormal serotonin signaling is not sufficient to generate the depressive behaviors, increasing D2r expression by chronic fluoxetine (Prozac) treatment or adenoassociated virus type2 (AAV2) mediated expression of Rxrgamma or D2r in the NAc of Rxrgamma(-/-) mice normalizes depressive-like behaviors in Rxrgamma(-/-) animals. Conversely, NAc infusion of raclopride, a D2r antagonist prevents AAV2-Rxrgamma-mediated rescue of despair behaviors in Rxrgamma(-/-) mice. Combined, our data argue that control of NAc D2r expression is critical for Rxrgamma-mediated modulation of affective behaviors.

References

Jan 1, 1976·European Journal of Pharmacology·A J PijnenburgJ M Van Rossum
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·C MessierC Destrade
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·W KrezelP Chambon
Jul 1, 1997·International Clinical Psychopharmacology·P Willner
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·T A SamadE Borrelli
Feb 3, 1999·Annals of the New York Academy of Sciences·P BlierC de Montigny
Dec 11, 1999·Psychopharmacology·A Dalvi, I Lucki
May 17, 2000·Depression and Anxiety·M H CorriganD L Evans
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·A M Ouagazzal, I Creese
Oct 4, 2002·Biological Psychiatry·Eric J NestlerSteve Zalcman
Feb 1, 2003·Biological Psychiatry·Pierre Blier, Nick M Ward
Feb 27, 2004·Psychopharmacology·Judith A Siuciak, Remie A Fujiwara
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie C DulawaRene Hen
Jul 29, 2004·Nutritional Neuroscience·K NaliwaikoA C Ferraz
Nov 19, 2004·Fundamental & Clinical Pharmacology·Eric DaillyMichel Bourin
Apr 12, 2005·Journal of Affective Disorders·Paul WillnerSpilios Argyropoulos
May 18, 2005·Learning & Memory·Marta WietrzychWojciech Krezel
May 24, 2005·Drugs·Malcolm Peet, Caroline Stokes
Sep 27, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xiao-Gang LiShin-Ichi Muramatsu
Mar 29, 2006·Biological Psychiatry·Eric J Nestler, William A Carlezon
Oct 3, 2006·Expert Review of Neurotherapeutics·Kevin F FoleyRichard E Kast
Aug 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Douglas Bremner, Peter McCaffery
Jan 22, 2009·Annals of General Psychiatry·Vassilis P KontaxakisGeorge N Papadimitriou

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Citations

Dec 7, 2010·Nature Neuroscience·Jeffrey K HuangRobin J M Franklin
Jun 8, 2013·Neurobiology of Learning and Memory·Emily A YoungChristopher L Cunningham
May 20, 2015·Journal of Neural Transmission·Julian Hellmann-RegenGolo Kronenberg
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Yoshiaki MiyamotoAtsumi Nitta
Jan 22, 2013·Pharmacology, Biochemistry, and Behavior·Madoka NakagomiAkiko Nakatani-Pawlak
Jan 15, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jane KovalevichDianne Langford
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Yoshiaki MiyamotoAtsumi Nitta
Oct 8, 2013·Journal of Molecular Endocrinology·Shannon E MullicanMitchell A Lazar
Jan 16, 2018·Nuclear Receptor Research·Shari BodofskyBruce Wightman
Jan 3, 2012·Endocrinology·Gisela HelferPeter J Morgan
May 31, 2020·Psychopharmacology·Eric Murillo-RodríguezPablo Torterolo
Aug 22, 2018·Frontiers in Physiology·Thomas Larrieu, Sophie Layé
Feb 20, 2020·Neuroscience and Biobehavioral Reviews·Pu HuJiang-Ning Zhou
Dec 28, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Katarzyna Sołtys, Andrzej Ożyhar
Feb 10, 2012·Development·Muriel Rhinn, Pascal Dollé
Jun 9, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hajime MiyanishiAtsumi Nitta
Aug 18, 2021·Neurobiology of Stress·Agnieszka KrzyżosiakWojciech Krężel

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