PMID: 9433644Jan 20, 1998Paper

Retinoids and chemoprevention of aerodigestive tract cancers

Cancer Metastasis Reviews
Reuben Lotan

Abstract

Natural and synthetic vitamin A metabolites and analogs (retinoids) were found to suppress head and neck and lung carcinogenesis in animal models and inhibit carcinogenesis in individuals with premalignant lesions and a high risk to develop cancer of the aerodigestive tract. Likewise, retinoids prevent the development of second primary cancers in head and neck and lung cancer patients who had been treated for the first primary. These effects are thought to result from changes in the expression of genes that regulate cell growth and differentiation. Most of the effects of retinoids on gene expression are mediated by nuclear retinoic acid receptors RARs (alpha, beta, and gamma) and retinoid X receptors (RXR alpha, beta, and gamma), which function as retinoid-activated transcription factors. Like vitamin A deficiency, alterations in receptor expression or function could interfere with the retinoid signaling pathway and thereby enhance cancer development even in vitamin A sufficient individuals. We found that the expression of RAR beta was suppressed in more than 50% of oral and lung premalignant lesions in individuals without cancer (e.g., oral leukoplakia and squamous metaplasia), in dysplastic lesions adjacent to cancer, and in ...Continue Reading

Citations

Sep 29, 1999·Journal of Neuroscience Research·M Alvarez-DoladoA Muñoz
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melanie B Thomas, James L Abbruzzese
May 28, 2008·Journal of Cancer Research and Clinical Oncology·Kimberly B HigginbothamMelanie B Thomas
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J AyoubW E Bradley
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Carsten-Henning OhlmannGabriele Jaques
Dec 21, 2016·Cancer Prevention Research·Donna E SeabloomFrank G Ondrey
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank Ondrey
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hajime OritaEdward Gabrielson
Jan 15, 1999·Hematology/oncology Clinics of North America·M You, G Bergman

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