Retinoids as modulators of metabolism: their inhibitory effect on cyclophosphamide and 7,12-dimethylbenz[a]anthracene induced sister chromatid exchanges in a metabolically competent cell line

Mutagenesis
R CozziR De Salvia

Abstract

Recently, retinoids have been studied for their ability to modify the carcinogenic/mutagenic activity of chemical compounds. Results show that they can inhibit the malignant transformation of cells, the induction of cancer in experimental animals and the mutagenicity of promutagens. Our experiments examine how retinol and retinoic acid can decrease the frequency of sister chromatid exchange (SCE) induced by two indirect mutagens/carcinogens (cyclophosphamide and 7,12-dimethylbenz[a]anthracene) in an epithelial liver cell line of male Chinese hamster (CHEL cells). These cells are metabolically competent and activate different classes of promutagens into biologically active metabolites. Our results are consistent with the suggestion that retinoids modulate the genotoxicity of indirect-acting mutagens by altering their metabolic activation or cellular detoxification processes or both.

Citations

Jun 1, 1992·Mutation Research·H E BrockmanM D Waters
Feb 19, 1996·Mutation Research·M D WatersS De Flora
Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R EdenharderH Dunkelberg
Jan 1, 1991·Environmental and Molecular Mutagenesis·R CozziS Polani
Jan 1, 1995·Environmental and Molecular Mutagenesis·R CozziR De Salvia
Feb 20, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G Avani, M V Rao

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