Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro

Gynecologic Oncology
Dennis R Scribner, D M Benbrook

Abstract

The aim of this study was to determine whether receptor-dependent and receptor-independent retinoids sensitize cervical cancer cells to clinically relevant doses of concurrent radiation and cisplatin. The clonogenic assay was performed on SiHa cervical carcinoma cultures treated with 5 microM 9-cis-retinoic acid (RA) or 3 microM 4-HPR for 3 days prior to and following concurrent treatment with 3 microM cisplatin and 2 Gy of Co(60) radiation. Neither 9-cis-RA nor 4-HPR significantly decreased survival for radiation only or cisplatin only (t test: P < 0.05), but both significantly decreased survival of cultures receiving concurrent chemoradiation (t test: 9-cis-RA P = 0.045; 4-HPR P = 0.027). Both receptor-dependent and receptor-independent retinoids enhance concurrent chemoradiation effects in vitro.

References

May 1, 1987·Journal of the American Academy of Dermatology·A K SilvermanJ J Voorhees
Jan 29, 1999·Cancer Chemotherapy and Pharmacology·G P Kalemkerian, X Ou

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Citations

Apr 12, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H YoshitakeY Araki
Jun 8, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shih-Han HungHow Tseng
Feb 22, 2003·Current Treatment Options in Oncology·Samir N Khleif
Dec 25, 2004·The International Journal of Biochemistry & Cell Biology·Shi PingXuanxian Peng
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Kong-Wang HuHao Li
Jul 14, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P C KaiserS Aebi

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