Retinol-binding protein-4 is not strongly associated with insulin sensitivity in normal pregnancies

European Journal of Endocrinology
T UelandJ Bollerslev

Abstract

Recently, experimental and clinical studies suggest that retinol-binding protein-4 (RBP4) may provide a link between obesity and insulin resistance. However, no previous studies have investigated the impact of circulating RBP4 on measures of insulin resistance in normal pregnant women, and the objective of this study is to measure serum RBP4 in early and late pregnancy and relate these to measures of insulin resistance and secretion controlling for changes in fat mass. Samples were obtained during oral glucose tolerance test (OGTT) from 44 normal pregnancies at weeks 14-16 and 30-32. Measures of fat mass were body mass index (BMI) and leptin while insulin sensitivity and secretion were predicted from OGTT. Leptin and RPB4 were measured by immunoassay. Insulin sensitivity decreased during the course of pregnancy. Insulin sensitivity and secretion were best explained by BMI and circulating leptin, but not RBP4, both in early and late pregnancy. However, a marked increase in fasting RBP4 from early to late pregnancy was observed, and this change was associated with a decline in insulin sensitivity. A marked increase in RBP4 was found during OGTT at weeks 14-16 with an opposite temporal course at weeks 30-32. The increased fat mass...Continue Reading

References

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Citations

Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Neda Rasouli, Philip A Kern
Aug 28, 2009·Journal of Perinatal Medicine·Edi VaisbuchJuan Pedro Kusanovic
Feb 17, 2010·Journal of Women's Health·Katharina KleinChristof Worda
Feb 16, 2013·Metabolism: Clinical and Experimental·Surabhi NandaKypros H Nicolaides
Jul 12, 2011·Metabolism: Clinical and Experimental·Weerapan KhovidhunkitThipaporn Tharavanij
Oct 12, 2010·Clinical Biochemistry·Hyun-Jung KimChan-Wha Kim
Jul 4, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xuejun ShangguanMinyue Dong
Sep 29, 2011·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
Jan 2, 2018·World Journal of Diabetes·AbdelHameed Mirghani Dirar, John Doupis
Sep 16, 2010·Annals of the New York Academy of Sciences·G ValsamakisG Mastorakos
Sep 10, 2015·Hormone Molecular Biology and Clinical Investigation·Emilio Herrera, Gernot Desoye
Oct 2, 2020·Current Developments in Nutrition·Bryan M GannonSaurabh Mehta

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