Retinol-binding protein gene is highly expressed in higher-order association areas of the primate neocortex

Cerebral Cortex
Yusuke KomatsuTetsuo Yamamori

Abstract

The neocortex consists of histochemically, connectionally, and functionally distinguishable areas. Recently, molecular biological techniques have enabled us to find rare types of genes expressed in specific neocortical areas. We previously reported occ1 gene as preferentially expressed in the primary visual cortex (V1), using the differential display method. Here, by differential display, we found selective and strong expression of the serum retinol-binding protein (RBP) gene, in higher-order association areas. In V1, RBP mRNA was expressed only in the superficial part of layer II, but its expression increased, involving deeper layers, along the visual pathway. In visual association areas such as TE, RBP mRNA was strongly expressed in both supra- and infragranular layers. In primary auditory and somatosensory areas, as in V1, RBP expression was low, and restricted to the upper part of the supragranular layers. The laminar pattern of RBP expression is in marked contrast with that of occ1; and in early visual areas where both genes are expressed, these occur in distinct sublayers within the supragranular layers. In neonatal monkeys, the area-specific expression pattern of RBP was less distinct, suggesting that the characteristic ...Continue Reading

Citations

Jun 6, 2013·Stem Cells and Development·Barbara OrsolitsZsuzsanna Környei
Oct 27, 2006·Cerebral Cortex·Akiya WatakabeTetsuo Yamamori
Dec 17, 2008·Cerebral Cortex·Toru TakahataTetsuo Yamamori
Mar 10, 2010·Cerebral Cortex·Noritaka IchinoheKathleen S Rockland
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marcello G P Rosa, Rowan Tweedale
Jan 19, 2006·Genes, Brain, and Behavior·A WatakabeT Yamamori
Sep 22, 2012·Journal of the American Society of Nephrology : JASN·Hideyuki ItoMotoaki Sano
Jun 7, 2014·Frontiers in Systems Neuroscience·Akiya WatakabeTetsuo Yamamori
Sep 1, 2007·Biochemical and Biophysical Research Communications·Akira SatoToshio Kojima
Mar 21, 2006·Neuroscience Research·Tetsuo Yamamori, Kathleen S Rockland
Dec 6, 2005·Brain Research Reviews·Joana Almeida Palha, Ann B Goodman
Jun 23, 2012·Nature·Masaharu KinoshitaTadashi Isa
Jun 13, 2012·Hippocampus·Timothy GoodmanPeter McCaffery
Sep 24, 2020·Annual Review of Nutrition·Marta U Wołoszynowska-FraserPeter McCaffery
Aug 18, 2020·Expert Opinion on Drug Metabolism & Toxicology·Jason Nicol ClarkPeter McCaffery
Oct 6, 2005·Neuroscience·T MiyashitaK S Rockland
Jul 20, 2010·Methods : a Companion to Methods in Enzymology·Akiya WatakabeTetsuo Yamamori

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