Retinol saturase promotes adipogenesis and is downregulated in obesity.

Proceedings of the National Academy of Sciences of the United States of America
Michael SchuppMitchell A Lazar

Abstract

Adipocyte differentiation is controlled by many transcription factors, but few known downstream targets of these factors are necessary for adipogenesis. Here we report that retinol saturase (RetSat), which is an enzyme implicated in the generation of dihydroretinoid metabolites, is induced during adipogenesis and is directly regulated by the transcription factor peroxisome proliferator activated receptor gamma (PPARgamma). Ablation of RetSat dramatically inhibited adipogenesis but, surprisingly, this block was not overcome by the putative product of RetSat enzymatic activity. On the other hand, ectopic RetSat with an intact, but not a mutated, FAD/NAD dinucleotide-binding motif increased endogenous PPARgamma transcriptional activity and promoted adipogenesis. Indeed, RetSat was not required for adipogenesis when cells were provided with exogenous PPARgamma ligands. In adipose tissue, RetSat is expressed in adipocytes but is unexpectedly downregulated in obesity, most likely owing to infiltration of macrophages that we demonstrate to repress RetSat expression. Thiazolidinedione treatment reversed low RetSat expression in adipose tissue of obese mice. Thus, RetSat plays an important role in the biology of adipocytes, where it fav...Continue Reading

References

Oct 1, 1982·The Journal of Clinical Investigation·P J HissinS W Cushman
Jul 28, 1995·Science·M A PelleymounterF Collins
Mar 1, 1997·Molecular and Cellular Biology·E J SchwarzM A Lazar
Jun 17, 1998·The Journal of Biological Chemistry·B P ZhouC W Abell
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Apr 20, 2004·Biochemical and Biophysical Research Communications·Xiaolin YangUlf Smith
Sep 11, 2004·The Journal of Biological Chemistry·Alexander R MoiseKrzysztof Palczewski
Aug 24, 2005·The Journal of Biological Chemistry·Sheila M O'ByrneWilliam S Blaner
Sep 20, 2006·The Journal of Experimental Medicine·Istvan SzatmariLaszlo Nagy
Oct 3, 2006·Cell Metabolism·Stephen R Farmer
Oct 13, 2006·Obesity·Severine G DuboisUNKNOWN Look AHEAD Adipose Research Group
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Dec 15, 2006·Nature·Evan D Rosen, Bruce M Spiegelman
Feb 6, 2007·Cell Metabolism·Kevin J CheungJeffrey M Friedman
Feb 27, 2007·Cell·Bradley E BernsteinEric S Lander
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Cell·Bing LiJerry L Workman
Mar 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Wei LiaoJerrold M Olefsky
May 29, 2007·Nature Medicine·Ouliana ZiouzenkovaJorge Plutzky
Jun 19, 2007·Genes & Development·Mohammed Qatanani, Mitchell A Lazar
Aug 25, 2007·The Journal of Clinical Investigation·Ja-Young KimPhilipp E Scherer
Sep 13, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·Gennaro Taibi, Concetta M A Nicotra
Jan 9, 2008·Journal of the American Chemical Society·Alexander R MoiseKrzysztof Palczewski

❮ Previous
Next ❯

Citations

Nov 26, 2013·Chemical Reviews·Rosana ÁlvarezÁngel R de Lera
Oct 20, 2010·The Journal of Biological Chemistry·Michael Schupp, Mitchell A Lazar
Dec 24, 2010·Nucleic Acids Research·Andreas ProkeschZlatko Trajanoski
Nov 27, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander R MoiseKrzysztof Palczewski
Aug 28, 2009·Genes & Development·Nan WuMitchell A Lazar
Sep 23, 2009·Molecular Pharmacology·Alexander R MoiseKrzysztof Palczewski
May 26, 2010·Molecular and Cellular Biology·C F ZizolaS Vogel
Feb 14, 2012·Journal of Lipid Research·Elizabeth P NewberryNicholas O Davidson
Jan 19, 2012·Nutrients·Simone K Frey, Silke Vogel
Dec 4, 2012·Nutrients·Jean-François LandrierFranck Tourniaire
Apr 30, 2013·Journal of Lipid Research·Sheila M O'Byrne, William S Blaner
Dec 26, 2015·Progress in Lipid Research·Philip HallenborgKarsten Kristiansen
Jun 29, 2011·The Journal of Physiology·Débora S A ColombariJulian F R Paton
Jun 28, 2011·Biochimica Et Biophysica Acta·Rumana YasmeenOuliana Ziouzenkova
Jun 15, 2011·Biochimica Et Biophysica Acta·M Luisa BonetAndreu Palou
Aug 31, 2014·Nutrition Research·Kimberly M JeckelMelinda A Frye
Nov 3, 2015·Scientific Reports·Steven E TrasinoLorraine J Gudas
Sep 14, 2013·Molecular & Cellular Proteomics : MCP·Yurong GuoSusan S Taylor
Jun 28, 2012·Diabetes & Metabolism Journal·Eun-Jung Rhee, Jorge Plutzky
Jan 14, 2020·Genome Génome / Conseil National De Recherches Canada·Yuanlang WangYueyun Ding
Jul 15, 2020·American Journal of Physiology. Endocrinology and Metabolism·Valter T BoldarineEliane B Ribeiro
Jun 11, 2011·The Journal of Biological Chemistry·Chad DeisenrothYanping Zhang
Jan 13, 2015·The Journal of Biological Chemistry·Yan-Yun LiuGregory A Brent
Mar 28, 2012·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Ana Luisa Marcucci Leão, Luana Caroline dos Santos
Sep 1, 2017·Nature Communications·Steffi HeidenreichMichael Schupp
Jul 7, 2018·Environmental Science and Pollution Research International·Yunbo ZhangXiaolin Na
Jan 19, 2021·Journal of Dairy Science·Joel Ira WellerEphraim Ezra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.