PMID: 11328675May 1, 2001Paper

Retinol supplementation induces oxidative stress and modulates antioxidant enzyme activities in rat sertoli cells

Free Radical Research
F Dal-PizzolJ C Moreira

Abstract

Recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer. Recently the causal mechanism has begun to be clarified. We report here that retinol caused cellular oxidative stress and modulated superoxide dismutase, catalase and glutathione peroxidase activities. Retinol (7 microM) significantly increased TBARS, conjugated dienes, and hydroperoxide-initiated chemiluminescence in cultured Sertoli cells. In response to retinol treatment superoxide dismutase, catalase and glutathione peroxidase activities increased. TBARS content and catalase activities were decreased by a free radical scavenger. These findings suggest that retinol may induce oxidative stress and modulate antioxidant enzyme activities in Sertoli cells.

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Citations

Mar 26, 2008·Journal of Medicinal Food·Caroline DaniJoão A P Henriques
Oct 28, 2009·Journal of Medicinal Food·Caroline DaniJoão Antonio Pegas Henriques
Jan 1, 2010·Journal of Medicinal Food·Matheus Augusto de Bittencourt PasqualiJosé Cláudio Fonseca Moreira
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