Retinol (Vitamin A) Increases α-Synuclein, β-Amyloid Peptide, Tau Phosphorylation and RAGE Content in Human SH-SY5Y Neuronal Cell Line

Neurochemical Research
Alice KunzlerDaniel Pens Gelain

Abstract

Retinoids (vitamin A and derivatives) are recognized as essential factors for central nervous system (CNS) development. Retinol (vitamin A) also was postulated to be a major antioxidant component of diet as it modulates reactive species (RS) production and oxidative stress in biological systems. Oxidative stress plays a major role either in pathogenesis or development of neurodegenerative diseases, or even in both. Here we investigate the role of retinol supplementation to human neuron-derived SH-SY5Y cells over RS production and biochemical markers associated to neurodegenerative diseases expressed at neuronal level in Parkinson's disease and Alzheimer's disease: α-synuclein, β-amyloid peptide, tau phosphorylation and RAGE. Retinol treatment (24 h) impaired cell viability and increased intracellular RS production at the highest concentrations (7 up to 20 µM). Antioxidant co-treatment (Trolox 100 µM) rescued cell viability and inhibited RS production. Furthermore, retinol (10 µM) increased the levels of α-synuclein, tau phosphorylation at Ser396, β-amyloid peptide and RAGE. Co-treatment with antioxidant Trolox inhibited the increased in RAGE, but not the effect of retinol on α-synuclein, tau phosphorylation and β-amyloid peptid...Continue Reading

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Citations

Mar 5, 2019·Journal of Periodontal Research·Karim M Fawzy El-SayedChristof E Dörfer
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Rongzi LiJeganathan Ramesh Babu
Oct 23, 2020·Critical Reviews in Food Science and Nutrition·Sanskriti VatsRupesh Deshmukh
Apr 7, 2021·Journal of Microbiology and Biotechnology·Sivakumar LingappaPalaniappan Seedevi

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Methods Mentioned

BETA
electrophoresis
transgenic

Software Mentioned

GraphPad
Image J

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