PMID: 3753693Jan 1, 1986Paper

Retinopathy of prematurity: the influence of gestational age and retinal maturity on the statistical behavior of risk factors

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
F KoernerB Flury

Abstract

The clinical and laboratory data on 140 premature infants, 74 cases with retinopathy of prematurity (ROP) and 66 control cases without ROP, were correlated with ROP grades of increasing severity. By using multiple linear regression (MLR), it is shown that for predicting ROP grades the importance of certain variables varies considerably depending on the gestational age. Below 32 weeks of gestation, acidosis, hyperoxemia, gestational age, pathologic paCO2 levels, and multiple birth are strong regressors. Above 31 weeks, the most important regressors are multiple birth and acidosis, while gestational age and duration of FiO2 greater than 0.4 are much less influential. Blood transfusions and artificial ventilation do not seem important in the MLR of either group. When ROP is regressed on the number of paO2 values above 100 torr and gestational age or on the number of paCO2 values above 50 torr and gestational age, the regression coefficients of these variables drop to near zero at a gestational age of about 32 weeks. This loss of weight of the two variables paO2 and paCO2 with increasing gestational age coincides with a comparable drop of the relative incidence of ROP and the relative incidence of immature retinal vessels. It is hy...Continue Reading

References

Jan 1, 1977·Archives of Ophthalmology·B J KushnerJ T Flynn

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Citations

Nov 24, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·John P BerdahlJonathan M Holmes
Dec 5, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joao Borges Fortes FilhoRenato S Procianoy
Dec 18, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joao Borges Fortes FilhoRenato Soibelmann Procianoy
Apr 7, 2020·Journal of Neonatal-perinatal Medicine·Saif Aldeen AlRyalatAllaa Roto
Mar 1, 1995·Intensive Care Medicine·E Bossi, F Koerner
Apr 22, 2018·Survey of Ophthalmology·Sang Jin KimMichael F Chiang
Sep 1, 1992·Current Problems in Pediatrics·D L Phelps

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