Abstract
In the present study, we aimed at better understanding the short (acute) and long term (chronic) degenerative processes characterizing the juvenile rat model of light-induced retinopathy. Electroretinograms, visual evoked potentials (VEP), retinal histology and western blots were obtained from juvenile albino Sprague-Dawley rats at preselected postnatal ages (from P30 to P400) following exposure to 10,000 lux from P14 to P28. Our results show that while immediately following the cessation of exposure, photoreceptor degeneration was concentrated within a well delineated area of the superior retina (i.e. the photoreceptor hole), with time, this hole continued to expand to form an almost photoreceptor-free region covering most of superior-inferior axis. By the end of the first year of life, only few photoreceptors remained in the far periphery of the superior hemiretina. Interestingly, despite a significant impairment of the outer retinal function, the retinal output (VEP) was maintained in the early phase of this retinopathy. Our findings thus suggest that postnatal exposure to a bright luminous environment triggers a degenerative process that continues to impair the retinal structure and function (mostly at the photoreceptor lev...Continue Reading
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Citations
Feb 1, 2017·Current Eye Research·Anna PolosaPierre Lachapelle
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzRobin Roberts
Oct 29, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Samaneh ChaychiPierre Lachapelle
Jun 30, 2016·PloS One·Anna PolosaPierre Lachapelle
Jun 7, 2019·International Journal of Molecular Sciences·Anna PolosaPierre Lachapelle