Retinotopic Separation of Nasal and Temporal Motion Selectivity in the Mouse Superior Colliculus

Current Biology : CB
Daniel de MalmazetKarl Farrow

Abstract

Sensory neurons often display an ordered spatial arrangement that enhances the encoding of specific features on different sides of natural borders in the visual field (for example, [1-3]). In central visual areas, one prominent natural border is formed by the confluence of information from the two eyes, the monocular-binocular border [4]. Here, we investigate whether receptive field properties of neurons in the mouse superior colliculus show any systematic organization about the monocular-binocular border. The superior colliculus is a layered midbrain structure that plays a significant role in the orienting responses of the eye, head, and body [5]. Its superficial layers receive direct input from the majority of retinal ganglion cells and are retinotopically organized [6, 7]. Using two-photon calcium imaging, we recorded the activity of collicular neurons from the superficial layers of awake mice and determined their direction selectivity, orientation selectivity, and retinotopic location. This revealed that nearby direction-selective neurons have a strong tendency to prefer the same motion direction. In retinotopic space, the local preference of direction-selective neurons shows a sharp transition in the preference for nasal v...Continue Reading

Citations

Apr 15, 2020·ELife·Kyu Hyun LeeMarkus Meister
Aug 5, 2020·Current Biology : CB·Rune Rasmussen, Keisuke Yonehara
Jul 11, 2020·Current Biology : CB·Ya-Tang LiMarkus Meister

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