Retinovascular physiology and pathophysiology: new experimental approach/new insights.

Progress in Retinal and Eye Research
D G Puro

Abstract

An important challenge in visual neuroscience is to understand the physiology and pathophysiology of the intra-retinal vasculature, whose function is required for ophthalmoception by humans and most other mammals. In the quest to learn more about this highly specialized portion of the circulatory system, a newly developed method for isolating vast microvascular complexes from the rodent retina has opened the way for using techniques such as patch-clamping, fluorescence imaging and time-lapse photography to elucidate the functional organization of a capillary network and its pre-capillary arteriole. For example, the ability to obtain dual perforated-patch recordings from well-defined sites within an isolated microvascular complex permitted the first characterization of the electrotonic architecture of a capillary/arteriole unit. This analysis revealed that this operational unit is not simply a homogenous synctium, but has a complex functional organization that is dynamically modulated by extracellular signals such as angiotensin II. Another recent discovery is that a capillary and its pre-capillary arteriole have distinct physiological differences; capillaries have an abundance of ATP-sensitive potassium (K(ATP)) channels and a ...Continue Reading

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Citations

Feb 22, 2012·American Journal of Physiology. Cell Physiology·Masanori FukumotoDonald G Puro
Jan 10, 2014·The Journal of Clinical Investigation·Christoph HeinzeChristian A Hübner
Mar 4, 2014·Progress in Retinal and Eye Research·Dao-Yi YuEr-Ning Su
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Jul 31, 2013·Progress in Retinal and Eye Research·Toke Bek
Aug 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Donald G PuroDolly A Padovani-Claudio
Feb 9, 2017·Pharmacology & Therapeutics·Christine T O NguyenMagnus Ivarsson
Apr 6, 2019·The Journal of Comparative Neurology·Elena IvanovaBotir T Sagdullaev
Aug 21, 2019·Acta Neuropathologica Communications·Luis Alarcon-MartinezTurgay Dalkara
Sep 12, 2020·PloS One·Maxwell SingerAmir H Kashani
Aug 12, 2020·Visual Neuroscience·Cyril G EleftheriouBotir T Sagdullaev
Sep 14, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Stefan PalkovitsLeopold Schmetterer
Mar 9, 2021·Investigative Ophthalmology & Visual Science·Toke Bek, Signe Krejberg Jeppesen
Nov 24, 2021·The Journal of Comparative Neurology·Elena IvanovaBotir T Sagdullaev

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