Retinyl palmitate flexible polymeric nanocapsules: characterization and permeation studies

Colloids and Surfaces. B, Biointerfaces
Zaine TeixeiraNelson Durán

Abstract

Polymeric nanocapsules with elastic characteristics were prepared by the pre-formed polymer interfacial deposition method. The system consists of an oily core of retinyl palmitate with Span 60 and a polymeric wall of poly(D,L-lactide) (PLA). A narrow size distribution (215 nm, P.D.I. 0.10) was showed by dynamic light scattering (DLS) analyses. Particle deformability was observed by transmission electron microscopy (TEM) images and permeation of the particles through two superposed membranes of smaller pore diameters. Permeation studies were achieved using plastic surgery abdominal human skin by Franz diffusion cell. Retinyl palmitate permeates into deep skin layers. Besides, a PLA fluorescent derivative conjugated with Nile blue dye by an amide covalent bound was additionally obtained. Permeation profile of the nanocapsules with the fluorescent polymer was evaluated by confocal laser scanning microscopy (CLSM). The CLSM showed that nanocapsules were distributed uniformly, suggesting that the permeation mechanism through skin is intercellular. Thus, the use of these nanocapsules may be a feasible strategy to enhance the permeation of actives into the skin when delivery to deep layers is aimed.

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Citations

Aug 8, 2014·BioMed Research International·Chiara DianzaniGiuseppina Barrera
Sep 14, 2013·The Journal of Pharmacy and Pharmacology·Sonja R VučenDragan Uskoković
Feb 3, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Luiza A FrankSilvia S Guterres
May 23, 2015·Therapeutic Delivery·Lívia Vieira DepieriMaria Vitória Lopes Badra Bentley
Jun 29, 2012·Journal of Colloid and Interface Science·Zaine TeixeiraNelson Durán
Jan 21, 2015·Nanomedicine·Javier O MoralesFelipe Oyarzun-Ampuero
Aug 11, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pravin ShendeR S Gaud
Feb 21, 2019·Journal of Cosmetic Dermatology·Sham AlZahabiAdham A Ramadan
Feb 6, 2020·Pharmaceutics·Eloy Pena-RodríguezFrancisco Fernández-Campos
Jun 21, 2020·Drug Delivery and Translational Research·R P GazziSilvia S Guterres
Aug 14, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Madhulika Pradhan Ajazuddin
Aug 1, 2021·Journal of Materials Science. Materials in Medicine·Kshitya Shetty, Atul P Sherje

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