RET/PTC fusion gene rearrangements in Japanese thyroid carcinomas

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Ken-ichi NibuJay L Rothstein

Abstract

The activation of RET proto-oncogene through chromosomal translocation is reported as being unique to papillary thyroid carcinomas. However, the reported prevalence of RET/PTC activation in papillary carcinoma was variable, and the clinical relevance of RET/PTC rearrangements in papillary carcinomas is still controversial. To investigate the roles of RET rearrangement in the carcinogenesis of papillary thyroid carcinoma, we have studied RET activation and p53 overexpression in various thyroid lesions of the Japanese population by immunohistochemical technique. RET activation and p53 overexpression were studied in 40 papillary carcinomas, 6 poorly differentiated carcinomas, 4 undifferentiated carcinomas, 2 medullary carcinomas, 2 follicular carcinomas and 19 follicular adenomas. RET activation was observed in 12 out of 40 papillary carcinomas, while no immunoreactivity of RET was detected in other lesions. P53 overexpression was observed in only 1 of 40 papillary carcinomas, but in 2 poorly differentiated carcinomas and 4 undifferentiated carcinomas. The prevalence of RET/PTC activation in papillary carcinoma among the Japanese population was higher than in previous reports. Immunohistochemical technique is proved to be a useful...Continue Reading

References

Jul 1, 1992·Japanese Journal of Cancer Research : Gann·W WajjwalkuM Takahashi
Jan 1, 1995·Critical Reviews in Oncogenesis·M Takahashi
Jul 21, 1998·Thyroid : Official Journal of the American Thyroid Association·T MotomuraJ A Fagin
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C C CheungS L Asa
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Nov 15, 2001·Advances in Anatomic Pathology·G Tallini, S L Asa
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Massimo SantoroGiovanni Tallini

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Citations

Oct 6, 2015·Endocrinology and Metabolism·Young Shin SongYoung Joo Park
Mar 1, 2006·Virchows Archiv : an International Journal of Pathology·Kurt Werner Schmid, Nadir Rashad Farid

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