Retreatment of hepatitis C patients with pegylated interferon combined with ribavirin in non-responders to interferon plus ribavirin. Is it different in real life?

BMC Infectious Diseases
Fernando Lopes GonçalesNeiva Sellan Gonçales

Abstract

More than 50% of hepatitis C viruses (HCV)-infected patients do not respond to the classical Interferon (IFN)/Ribavirin (RBV) combination therapy. The aim of this study was to evaluate the efficacy of retreatment with Peg-Interferon alpha-2b (PEG-IFN alpha-2b) plus RBV, in patients with HCV, genotypes 1 or 3, who were non-responders to the previous standard treatment with IFN/RBV. In the period 2005-2007, a total of 238 HCV chronic patients were non-responders to previous treatment with IFN plus RBV. Of these 130 agreed to be retreated with PEG-IFN alpha-2b and participated in this evaluation (90 with genotype 1 HCV and 40 with genotype 3 HCV). Patients were retreated at assisted IFN application hubs in compliance with the country's public health system rules. They received subcutaneous PEG-IFN alpha-2b, 1.5 microg, once weekly, associated with RBV, through the oral route, with doses determined according to weight (1,000 mg if weight <or= 75 kg and 1,250 mg if > 75 kg). Patients with genotype 1 HCV were retreated for over 48 weeks and patients with genotype 3 HCV for over 24 weeks. HCV-RNA was tested by polymerase chain reaction (PCR) at baseline, at week 12, at the end of the treatment, and 6 months thereafter. The predictiven...Continue Reading

References

Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Apr 2, 2004·Gastroenterology·Mitchell L ShiffmanUNKNOWN Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis Trial Group
Aug 6, 2005·Journal of Hepatology·Edward L KrawittUNKNOWN New York New England Study Team
Jun 13, 2006·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·E PariseUNKNOWN Brazilian Pegasys Cooperative Study Group
Feb 13, 2007·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Fernando Lopes Gonçales JrMaria Lúcia Gomes Ferraz
Oct 25, 2012·Srpski arhiv za celokupno lekarstvo·Milena BožićIvana Milošević

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Citations

Sep 28, 2013·Gut and Liver·Hyun Chin ChoSeung Woon Paik
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Mar 15, 2012·Memórias do Instituto Oswaldo Cruz·Francisco Kennedy Scofoni Faleiros de AzevedoFrancisco José Dutra Souto
Jul 18, 2014·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)

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Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

SAS Statistical Analysis System )

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