PMID: 3756787Oct 15, 1986Paper

Retreatment of pediatric brain tumors with radiation and misonidazole. Results of a CCSG/RTOG phase I/II study

Cancer
W M WaraM S Edwards

Abstract

Twenty-nine patients with recurrent pediatric brain tumors after full-dose treatment with radiation were retreated with misonidazole (9 gm/m2) and whole-brain irradiation (300 rad X 10). Seventeen of 29 patients (59%) experienced nausea and vomiting with misonidazole administration and 6 patients (21%) developed peripheral neuropathy. Serum levels of misonidazole were similar to those reported for adults. One patient died of trauma shortly after retreatment. For the remaining 28 patients, the median time-to-progression was 5.5 months. Median survival was 13 months. Six patients (21%) developed radiation toxicity, two of whom died from the toxicity. Whereas the results on this study are similar to reported series of patients receiving salvage chemotherapy for recurrent pediatric brain tumors, more effective treatment clearly is needed.

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Citations

Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·G S BaumanD A Larson
Dec 9, 1997·Pediatric Neurology·M C Chamberlain, P A Kormanik
Aug 1, 1997·American Journal of Clinical Oncology·H K KimH M Sandler
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R SchoenthalerD A Larson
Jul 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerL D Lunsford
Apr 16, 2011·Cancer·Richard L BakstSuzanne L Wolden
Jan 1, 2011·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Marzanna ChojnackaDanuta Perek
Feb 9, 2006·Pediatric Neurosurgery·Masamitsu AbeJunichi Imamura

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