Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Nature Neuroscience
Maria WimberMichael C Anderson

Abstract

Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. The effect of this proposed inhibition process on competing memories has, however, never been observed, as behavioral methods are 'blind' to retrieval dynamics and neuroimaging methods have not isolated retrieval of individual memories. We developed a canonical template tracking method to quantify the activation state of individual target memories and competitors during retrieval. This method revealed that repeatedly retrieving target memories suppressed cortical patterns unique to competitors. Pattern suppression was related to engagement of prefrontal regions that have been implicated in resolving retrieval competition and, critically, predicted later forgetting. Thus, our findings demonstrate a cortical pattern suppression mechanism through which remembering adaptively shapes which aspects of our past remain accessible.

References

Jan 1, 1995·Annual Review of Neuroscience·R Desimone, J Duncan
Jan 1, 1995·Psychological Review·M C Anderson, B A Spellman
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Alvarez, L R Squire
Sep 22, 2001·Neuropsychologia·S Kastner, L G Ungerleider
Apr 28, 2004·NeuroImage·Paul M MaceyRonald M Harper
Apr 9, 2005·Journal of Cognitive Neuroscience·Adam GazzaleyMark D'Esposito
Dec 24, 2005·Science·Sean M PolynKenneth A Norman
Jun 13, 2006·Neural Computation·Kenneth A NormanSean Polyn
Jun 15, 2007·Nature Neuroscience·Brice A KuhlAnthony D Wagner
Aug 7, 2007·Neuropsychologia·David Badre, Anthony D Wagner
Jun 20, 2008·Journal of Cognitive Neuroscience·Maria WimberKarl-Heinz Bäuml
Sep 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Timothy F BradyAude Oliva
Nov 5, 2008·Frontiers in Neuroscience·Alexander Borst
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria WimberAlan Richardson-Klavehn
Feb 21, 2009·Nature Reviews. Neuroscience·Karim Nader, Oliver Hardt
Mar 19, 2009·Psychonomic Bulletin & Review·Jeffrey N RouderGeoffrey Iverson
Mar 17, 2010·Current Biology : CB·Martin J ChadwickEleanor A Maguire
Oct 29, 2010·Nature·Moran CerfItzhak Fried
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brice A KuhlAnthony D Wagner
Nov 22, 2011·Neuron·Marvin M Chun, Marcia K Johnson
Jan 3, 2012·Trends in Cognitive Sciences·Adam Gazzaley, Anna C Nobre
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brice A KuhlMarvin M Chun
May 4, 2012·Memory & Cognition·Benjamin C Storm, Benjamin J Levy
Jan 1, 2011·Translational Psychiatry·M WimberA Richardson-Klavehn
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katharina N SeidlSabine Kastner
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernhard P StaresinaArjen Alink
Dec 18, 2012·Nature Neuroscience·Mototaka Suzuki, Jacqueline Gottlieb
Feb 2, 2013·Trends in Cognitive Sciences·Oliver HardtLynn Nadel
Mar 19, 2013·Neuropsychologia·Greg J DetreKenneth A Norman
Jul 12, 2013·Annual Review of Neuroscience·Ryan F SquireTirin Moore
Jul 24, 2013·Trends in Cognitive Sciences·Nikolaus Kriegeskorte, Rogier A Kievit
Jun 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ghootae KimNicholas B Turk-Browne
Jun 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordan Poppenk, Kenneth A Norman

❮ Previous
Next ❯

Citations

Jan 8, 2016·Journal of Cognitive Neuroscience·Jesse RissmanAnthony D Wagner
Dec 17, 2015·Memory & Cognition·Tobias TempelChristian Frings
Sep 10, 2015·Journal of Cognitive Neuroscience·Rachael L Elward, Michael D Rugg
Jul 8, 2015·Frontiers in Computational Neuroscience·Julio ChapetonArmen Stepanyants
Jun 16, 2016·Frontiers in Systems Neuroscience·Marlieke T R van KesterenAnthony D Wagner
Nov 4, 2015·PloS One·Mickaël Antoine JosephGaël Malleret
Feb 24, 2017·Nature Neuroscience·Jonathan D CohenTheodore L Willke
Apr 8, 2017·Journal of Cognitive Neuroscience·Jordan Poppenk, Kenneth A Norman
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Renée M VisserEmily A Holmes
Apr 24, 2018·Annals of the New York Academy of Sciences·Peter Shepherdson, Klaus Oberauer
May 2, 2018·Annual Review of Neuroscience·Sheena A Josselyn, Paul W Frankland
Nov 6, 2018·ELife·Anouk Mariette van LoonChristian Nl Olivers
Apr 11, 2015·Nature Reviews. Neuroscience·Natasha Bray
Aug 24, 2018·Cerebral Cortex·Hongmi LeeBrice A Kuhl
Jan 10, 2020·Memory·Brittany M JeyeScott D Slotnick
Apr 10, 2020·The Journal of General Psychology·Toshihiro WakebeTomomi Sato
May 29, 2020·The European Journal of Neuroscience·Andrea Moreno
Jun 24, 2020·Journal of Cognitive Neuroscience·Jennifer C WeeksBradley R Buchsbaum
Aug 8, 2018·Scientific Reports·Nicole S RafidiKenneth A Norman
Jan 9, 2019·Frontiers in Behavioral Neuroscience·Concepción PadillaTeresa Bajo
Jul 6, 2020·Nature Communications·Lennart LuettgauGerhard Jocham
Oct 30, 2018·Frontiers in Psychology·Gabriel N FriedmanZiv M Williams
Jan 19, 2018·Brain and Neuroscience Advances·Nitin Williams, Richard N Henson
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Svenja Brodt, Steffen Gais
Mar 21, 2018·Scientific Reports·Roger JohanssonMikael Johansson
Nov 9, 2018·Nature Communications·Pedro BekinschteinMichael C Anderson
Jul 30, 2020·Scientific Reports·Katarzyna BobrowiczMathias Osvath
Dec 9, 2020·Nature Communications·Hyojeong KimJarrod A Lewis-Peacock
Sep 16, 2020·Annual Review of Psychology·Michael C Anderson, Justin C Hulbert

❮ Previous
Next ❯

Methods Mentioned

BETA
RSA

Software Mentioned

PickAtlas
RSA
SPM8
WFU pickatlas
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Cognitive Sciences
Michael C Anderson, Simon Hanslmayr
Cognitive, Affective & Behavioral Neuroscience
Simon HanslmayrKarl-Heinz Bäuml
Translational Psychiatry
Maria WimberAlan Richardson-Klavehn
© 2021 Meta ULC. All rights reserved