Retrieving Binary Answers Using Whole-Brain Activity Pattern Classification

Frontiers in Human Neuroscience
Norberto Eiji Nawa, Hiroshi Ando

Abstract

Multivariate pattern analysis (MVPA) has been successfully employed to advance our understanding of where and how information regarding different mental states is represented in the human brain, bringing new insights into how these states come to fruition, and providing a promising complement to the mass-univariate approach. Here, we employed MVPA to classify whole-brain activity patterns occurring in single fMRI scans, in order to retrieve binary answers from experiment participants. Five healthy volunteers performed two types of mental task while in the MRI scanner: counting down numbers and recalling positive autobiographical events. Data from these runs were used to train individual machine learning based classifiers that predicted which mental task was being performed based on the voxel-based brain activity patterns. On a different day, the same volunteers reentered the scanner and listened to six statements (e.g., "the month you were born is an odd number"), and were told to countdown numbers if the statement was true (yes) or recall positive events otherwise (no). The previously trained classifiers were then used to assign labels (yes/no) to the scans collected during the 24-second response periods following each one of ...Continue Reading

References

Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Nov 30, 2006·Human Brain Mapping·Stephen M LaConteXiaoping P Hu
Oct 28, 2008·NeuroImage·Catie ChangGary H Glover
Nov 4, 2008·Clinical Medicine : Journal of the Royal College of Physicians of London·Haibo DiSteven Laureys
Dec 17, 2008·NeuroImage·Francisco PereiraMatthew Botvinick
Apr 28, 2009·Nature Neuroscience·Nikolaus KriegeskorteChris I Baker
Oct 13, 2009·Progress in Brain Research·Adrian M OwenSteven Laureys
Feb 5, 2010·The New England Journal of Medicine·Martin M MontiSteven Laureys
Mar 17, 2010·Current Biology : CB·Martin J ChadwickEleanor A Maguire
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jesse RissmanAnthony D Wagner
Aug 10, 2010·NeuroImage·Ranganatha SitaramNiels Birbaumer
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorina NaciAdrian M Owen
Jul 19, 2013·PloS One·Kai Schreiber, Bart Krekelberg
Oct 4, 2013·Nature Reviews. Neuroscience·Davinia Fernández-Espejo, Adrian M Owen
May 16, 2014·PloS One·Norberto Eiji Nawa, Hiroshi Ando
May 23, 2014·NeuroImage·Zhi YangPeter Bandettini

❮ Previous
Next ❯

Software Mentioned

SPM
LIBSVM
PAM
RETROICOR
Automated Anatomical Labeling library ( AAL
MVPA
WFU PickAtlas toolbox
Presentation
MarsBaR
LOROCV

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.