Retroelements in the human MHC class II region

Trends in Genetics : TIG
G AnderssonL Rask

Abstract

Molecular genetic studies of the human major histocompatibility complex (MHC) have led to the identification of more than 200 genes. Besides the large number of genes in the MHC, densely clustered areas of retroelements have been identified. These include short and long interspersed elements (SINEs and LINEs), and human endogenous retroviruses (HERVs). The presence of retroelements in the MHC provides a clear example of how these elements affect the genome plasticity of the host. Comparative analyses of these retroelements have proven highly useful in evolutionary studies of the MHC. Recently, HERV-encoded superantigens have been implicated as candidate autoimmune genes in type I diabetes and multiple sclerosis. In addition, genetic analyses have revealed that autoimmune diseases show strong associations with MHC class II genes. The intriguing correlations between retroviral encoded antigens, MHC class II genes and the development of autoimmune disease merit intense future investigations of retroelements, in particular those endogenous retroviruses located in the MHC class II region proper.

References

Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Oct 1, 1992·Journal of Molecular Evolution·J JurkaA Milosavljevic
Jan 1, 1992·Annual Review of Immunology·L H Glimcher, C J Kara
May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M KriegA Perl
Dec 1, 1991·Chromosoma·D Taruscio, L Manuelidis
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S KambhuJ S Lee
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K GregersenJ Schwenzer
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D LarhammarP A Peterson
Jul 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Mnuková-FajdelováJ Klein
Jun 1, 1994·Trends in Genetics : TIG·W MakałowskiD Labuda
Sep 15, 1994·Nature·B CharlesworthW Stephan
Feb 1, 1994·Immunology Today·G AnderssonS Sigurdardóttir
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W E MayerJ Klein
Jan 12, 1996·Journal of Molecular Biology·S BeckJ Trowsdale
Jan 1, 1996·Journal of Molecular Evolution·M A BatzerE Zuckerkandl
Jan 1, 1996·Journal of Molecular Evolution·V Kapitonov, J Jurka
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R LöwerR Kurth
Jun 1, 1996·Journal of Molecular Evolution·Y SattaJ Klein
Nov 1, 1996·Human Immunology·R GongoraJ Klein
Dec 1, 1996·Current Opinion in Genetics & Development·A F Smit
Mar 1, 1997·Trends in Genetics : TIG·C PatienceR A Weiss
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·H PerronB Mandrand
Jul 28, 2009·Journal of Autism and Developmental Disorders·Samuel L OdomKara Hume

❮ Previous
Next ❯

Citations

Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E D Sverdlov
May 29, 2000·Journal of Biosciences·G KumaresanS Mathavan
Mar 7, 2008·Immunogenetics·Lynn M Herrmann-HoesingDonald P Knowles
Mar 6, 1999·Current Opinion in Plant Biology·P C Ronald
Mar 17, 2000·Brain Research. Brain Research Reviews·R H YolkenE F Torrey
Jul 25, 2012·Molecular Biology and Evolution·Gaby G M DoxiadisRonald E Bontrop
Mar 27, 2001·Evolution; International Journal of Organic Evolution·M G Kidwell, D R Lisch
May 13, 1999·Immunological Reviews·S Beck, J Trowsdale
Aug 13, 2008·Annual Review of Genetics·Patric Jern, John M Coffin
Aug 12, 2005·Cytogenetic and Genome Research·P MedstrandD L Mager
Nov 10, 2011·Viruses·Luis P Villarreal
Feb 5, 2010·Immunogenetics·Gaby G M DoxiadisRonald E Bontrop
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Malgorzata TrelaPaul B Rylance
Oct 28, 2010·American Journal of Medical Genetics. Part a·Amarilis Sanchez-ValleSeema R Lalani
Aug 29, 2009·Reviews in Medical Virology·Eva BaladaMiquel Vilardell-Tarrés
Feb 16, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Miranda K Adelman, John J Marchalonis
Mar 21, 2015·Acta Neuropsychiatrica·Roberto LozanoAsunción Pascual
Nov 9, 2004·Trends in Immunology·C Yung Yu, Caroline C Whitacre
Jul 9, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S SotgiuG Rosati
Jan 6, 2001·Memórias do Instituto Oswaldo Cruz·E de S Leal, P M Zanotto
Nov 9, 2005·Microscopy Research and Technique·Sara SzaboRobert F Garry
Sep 28, 1999·Current Opinion in Neurology·E Meinl
Mar 20, 2020·Critical Care : the Official Journal of the Critical Care Forum·Marine MommertUNKNOWN REALISM Study Group
Sep 27, 2018·Frontiers in Immunology·Nicole Grandi, Enzo Tramontano
May 20, 1998·Genome Research·S Sandmeyer
May 8, 2020·Cancers·Alicja SznarkowskaMagdalena Pilch
Mar 9, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maiken Kruse Kristensen, Tove Christensen
Mar 15, 2003·Rheumatic Diseases Clinics of North America·Andras Perl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.