PMID: 6159027Apr 1, 1980Paper

Retrograde axonal transport and neurotransmitter specificity

Bulletin Der Schweizerischen Akademie Der Medizinischen Wissenschaften
Peter Streit

Abstract

The hypothesis on transmitter specific, retrograde labeling of neuronal pathways and observations relevant to this hypothesis are discussed. After injection of (3H)-glycine into the pigeon optic tectum fast labeling of intrinsic elements in a restricted part of the subtectal n. isthmi, pars parvocellularis (Ipc), is found - strongly suggesting a rapid retrograde migration of radioactivity in neurons of the glycinergic Ipc-tectal pathway. Labeling of neuronal perikarya in the substantia nigra, in cell groups A8 and A10 and in the n. raphé dorsalis after (3H)-dopamine- and (3H)-serotonin-injection, however in the cortex and in the thalamus after (3H)-D-aspartate-injection into the rat caudoputamen and in the n. raphé dorsalis after (3H)-serotonin-injection but in the caudoputamen after (3H)-GABA-injection into the substantia nigra - all these patterns indicate a retrograde labeling with a certain - partly transmitter specific - selectivity in the pathways concerned. Transmitter related, retrograde transport may become a useful neuro-anatomical method. The cell biology and a possible biological function of the phenomenon remain to be investigated.

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