PMID: 6168983Aug 7, 1981Paper

Retrograde axonal transport mediates the onset of regenerative changes in the hypoglossal nucleus

Neuroscience Letters
H L FernandezS Mehler

Abstract

The hypoglossal nucleus was assayed for [14C]2-deoxyglucose uptake 24 h after axotomy with and without colchicine injections into the nerve proximal to the nerve transection. Colchicine effectively blocked the usual increase in [14C]2-deoxyglucose uptake seen after axotomy. The drug also blocked the transport of horseradish peroxidase from the tongue muscles to the hypoglossal nucleus which otherwise occurred within this time period. Distribution of [3H]colchicine showed that the drug remained localized within the nerve close to the injection point. These results suggest that retrograde axoplasmic flow is involved in the mechanism which initiates hypoglossal neuron regeneration.

References

Sep 1, 1975·Experimental Neurology·B Grafstein
Sep 22, 1972·Science·G Pilar, L Landmesser
Oct 25, 1974·Brain Research·H L Fernandez, B U Ramirez
Sep 29, 1970·Brain Research·B G Cragg
Dec 1, 1968·European Journal of Pharmacology·A Dahlström
Sep 1, 1980·Experimental Neurology·P Singer, S Mehler
Dec 1, 1980·Experimental Neurology·G W Kreutzberg, H Emmert

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Citations

Dec 1, 1986·Journal of the Neurological Sciences·L B DahlinW G McLean
Sep 23, 2014·Neuroscience·A DeFrancesco-LisowitzR E Zigmond
Apr 11, 2000·Microscopy Research and Technique·C Legay
Dec 22, 2019·The European Journal of Neuroscience·Deirdre A SackettRegina M Carelli
Jan 1, 1983·Journal of Neurobiology·H L Fernandez, J A Donoso

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