PMID: 6159541Oct 16, 1980Paper

Retrograde axonal transport of target tissue-derived macromolecules

Nature
I A Hendry, C E Hill

Abstract

Neurones depend on contact with their target tissues for survival and subsequent development. The protein, nerve growth factor (NGF), can be selectively taken up by sympathetic nerve terminals and reaches the neuronal perikaryon by a process of retrograde intra-axonal transport, suggesting that its role in vivo is to act as a target tissue-derived trophic factor. The development of the neurones of the chick ciliary ganglion requires the presence of structures derived from the optic cup. Several studies in vitro have shown that media conditioned by non-neuronal cells contain factors that result in the survival of neurones from ciliary ganglia. In particular, chick embryo iris, ciliary body and choroid contained large amounts of these factors indicating the presence of a target tissue-derived trophic factor for the cholinergic ciliary ganglion. This study demonstrates that neurones of the ciliary ganglion accumulate, by retrograde intra-axonal transport, proteins synthesized and released by optic tissues in culture.

Citations

Nov 19, 1984·Brain Research·Y MizrachiM Schwartz
May 1, 1993·Mechanisms of Ageing and Development·T Cowen
Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I A Hendry, D A Belford
Sep 30, 2000·Brain Research. Brain Research Reviews·A J ReynoldsI A Hendry
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·I A HendryK Heydon
Jul 1, 1996·Neurochemical Research·S O JohansonI A Hendry

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