Retrograde axonal transport of the alpha-subunit of the GTP-binding protein GZ in mouse sciatic nerve: a potential pathway for signal transduction in neurons

The European Journal of Neuroscience
M F CrouchI A Hendry

Abstract

We have utilized antibodies against the alpha subunit of GZ in fluorescence immunohistochemistry to determine whether this GTP-binding protein can translocate along nerves by intra-axonal transport. After ligation of the mouse sciatic nerve we found an increase in GZ-like immunoreactivity on the proximal and distal side with time, suggesting that the alpha subunit undergoes orthograde axonal transport and also returns to the cell body by retrograde axonal transport in the sciatic nerve. Unlike the retrograde transport of Gi alpha, shown in a previous study to be present in most sciatic axons, GZ alpha only accumulated in a subpopulation of axons, suggesting that different G-proteins could convey information specific to neuronal subtypes. These results support our proposal that GZ may play a second messenger role in communicating information from the terminals back to cell bodies. Gi alpha and GZ alpha may be representative of relatively stable signalling molecules by which the signal from some neurotrophic molecules can be translocated from the neuron periphery to the cell body without the need for the retrograde transport of the neurotrophic factor itself.

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Citations

Jul 7, 2001·Neuroscience·A B McGeachieUNKNOWN Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S E Bartlett, I A Hendry
Jun 3, 2005·Neuroreport·Sharon OleskevichIan A Hendry
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M L GrimesW C Mobley
Jul 1, 1996·Neurochemical Research·S O JohansonI A Hendry
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Peter Mombaerts
Nov 2, 2017·Journal of Ophthalmic & Vision Research·Jaya KaushikSavita Agarwal
Apr 21, 2001·Oncogene·M K Ho, Y H Wong
Jul 4, 2006·Neuropharmacology·Kwong J LeckIan A Hendry
Oct 16, 2010·Cellular Signalling·Hua MeiYung H Wong

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