Abstract
It remains controversial whether contemporary cerebral perfusion techniques, utilized during deep hypothermic circulatory arrest (DHCA), establish adequate perfusion to deep structures in the brain. This study aimed to investigate whether selective antegrade cerebral perfusion (SACP) or retrograde cerebral perfusion (RCP) can provide perfusion equally to various anatomical positions in the brain using metabolic evidence obtained from microdialysis. Eighteen piglets were randomly assigned to 40 min of circulatory arrest (CA) at 18°C without cerebral perfusion (DHCA group, n = 6) or with SACP (SACP group, n = 6) or RCP (RCP group, n = 6). Microdialysis parameters (glucose, lactate, pyruvate, and glutamate) were measured every 30 min in cortex and striatum. After 3 h of reperfusion, brain tissue was harvested for Western blot measurement of α-spectrin. After 40 min of CA, the DHCA group showed marked elevations of lactate and glycerol and a reduction in glucose in the microdialysis perfusate (all P < 0.05). The changes in glucose, lactate, and glycerol in the perfusate and α-spectrin expression in brain tissue were similar between cortex and striatum in the SACP group (all P > 0.05). In the RCP group, the cortex exhibited lower gl...Continue Reading
References
May 1, 1996·The Annals of Thoracic Surgery·J YeR Deslauriers
Dec 14, 1999·The Journal of Thoracic and Cardiovascular Surgery·C D KurthR Raghupathi
Aug 2, 2000·The Annals of Thoracic Surgery·T KazuiY Tamiya
Jan 13, 2001·The Annals of Thoracic Surgery·P DemersR Cartier
Jul 24, 2001·The Annals of Thoracic Surgery·Y OkitaS Kitamura
Feb 12, 2002·Scandinavian Cardiovascular Journal : SCJ·M PokelaT Juvonen
Feb 13, 2003·Advances in Experimental Medicine and Biology·Gregory SchearsAnna Pastuszko
Oct 8, 2003·The Annals of Thoracic Surgery·Marco Di EusanioNaoki Washiyama
Nov 13, 2003·European Journal of Pharmacology·Yoshikatsu Kanai, Matthias A Hediger
Feb 14, 2004·Stroke; a Journal of Cerebral Circulation·Asita S SarrafzadehAndreas W Unterberg
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Lars MathisenErik Fosse
Mar 6, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Peter PastuszkoAnna Pastuszko
Aug 28, 2007·The Annals of Thoracic Surgery·Arjet GegaJohn A Elefteriades
Nov 27, 2007·Expert Review of Cardiovascular Therapy·Efstratios Apostolakis, Jeffrey H Shuhaiber
Jun 2, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jorge SalazarRobert DiGeronimo
Jun 30, 2009·The Annals of Thoracic Surgery·Jorge D SalazarRobert DiGeronimo
Apr 27, 2010·The Annals of Thoracic Surgery·Rita Karianna MilewskiJoseph E Bavaria
Feb 25, 2014·Critical Care Medicine·Meng-Ya LiangZhong-Kai Wu
Dec 3, 2014·The Journal of Thoracic and Cardiovascular Surgery·Yutaka OkitaUNKNOWN Japan Cardiovascular Surgery Database Organization