PMID: 9786078Oct 24, 1998

Retrograde coronary venous infusion of ethanol for ablation of canine ventricular myocardium

Journal of Cardiovascular Electrophysiology
K N WrightG N Kay

Abstract

Permanent cure of reentrant ventricular tachycardia (VT) associated with coronary artery disease is difficult to achieve. Retrograde coronary venous infusion of ethanol for ablation of ventricular myocardium associated with reentrant tachyarrhythmias has several potential advantages, including use of physiologic mapping techniques and production of deeper, wider necrotic zones. Nine anesthetized dogs had baseline hemodynamic measurement, left ventriculography, coronary arteriography, occlusive coronary venography, and programmed electrical stimulation of the right ventricular apex and outflow tract. A balloon-tipped infusion catheter was advanced into a distal coronary venous branch, the balloon slowly inflated, and pure ethanol infused at volumes of 1.5, 3, or 5 cc. Hemodynamic measurements, angiography, ventriculography, and programmed electrical stimulation were repeated immediately and 1 week following ablation. Formalin-perfused hearts were serially sectioned and lesion volumes determined. Histologic examination of ablation beds then was performed. No significant difference was found in any hemodynamic measurement before or after ablation. Coronary arteriograms and left ventriculograms were unchanged after ablation. Nonsus...Continue Reading

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Related Concepts

Necrosis
Ethanol
Catheterization
Ethanol Measurement
Formalin
Coronary Artery Disease
Left Ventricular Structure
Gated Blood-Pool Imaging
Isolated Noncompaction of the Ventricular Myocardium
Toxic Effect of Formaldehyde

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