Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine.

BMJ Case Reports
Matthew Roughley, Marc Lyall

Abstract

Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.

References

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Nov 12, 2005·Journal of Clinical Psychopharmacology·Angel Luis Montejo GonzálezUNKNOWN Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction
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Citations

Jan 21, 2021·Journal of Clinical Medicine·Angel L MontejoLaura Montejo
Jun 26, 2021·The World Journal of Men's Health·Sajal GuptaGiovanni M Colpi

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Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

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