Retrograde tracing of zinc-enriched (ZEN) neuronal somata in rat spinal cord

Brain Research
Zhan-You WangH D Schrøder

Abstract

The zinc selenide autometallographic (ZnSeAMG) technique for tracing the retrograde axonal transport of zinc ions in zinc-enriched (ZEN) neurons was used to map the distribution of ZEN neuronal somata in rat spinal cord. After a local injection of sodium selenide into the dorsal or ventral horn, ZnSeAMG-labeled ZEN neurons appeared in Rexed's laminae V, VII and X while laminae I and II were void. A few scattered ZEN somata were observed in the remaining laminae. The labeled neurons differed in shape and size, and the relatively high level of labeled somata around the injection site suggests that many ZEN neurons have relatively short axons or boutons en passage close to the neuronal origin. Ultrastructurally, the retrogradely transported zinc selenide clusters were found in the lysosomes of ZEN somata and proximal dendrites. Electron microscopic studies also revealed two different kinds of ZEN terminals: (1) terminals with flat synaptic vesicles making symmetric synaptic contacts; and (2) terminals with round vesicles making asymmetric synaptic contacts. The present study suggests the existence of propriospinal systems of ZEN neurons comprising both segmental and intersegmental ZEN connections and having either inhibitory or ex...Continue Reading

Citations

Aug 25, 2012·Cell and Tissue Research·Joanna WojtkiewiczSławomir Gonkowski
Aug 21, 2008·Neurochemical Research·Zhan-You Wang, Annica Dahlström
Jun 17, 2009·Journal of Neuroscience Research·Luisa Belloni-OliviJoseph Bressler
Feb 3, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Gorm Danscher, Meredin Stoltenberg
Jun 16, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Seung Mook JoSang Won Suh
Jul 17, 2004·Neuroreport·Zhan-You WangGorm Danscher
Jun 2, 2005·Progress in Neurobiology·Eugenio MocchegianiMarco Malavolta

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