PMID: 7260836Mar 1, 1980Paper

Retroperitoneal rhabdomyosarcoma in children. Results of multimodality therapy

Cancer
J L RansomD Bowles

Abstract

The clinical course of 18 consecutive children treated for primary retroperitoneal rhabdomyosarcoma was reviewed. At diagnosis, 8 patients had regional unresected tumor and 10 patients had disseminated tumor, including 3 patients with documented bone marrow infiltration by tumor. Following combined modality therapy, 14 of 18 patients achieved a greater than 50% tumor response (11 complete and 3 partial responses); 4 patients failed to respond and died of progressive disease within eight months of diagnosis. Among the 14 patients responding, 7 patients had subsequent reextension of active tumor three to 16 months (median, 9 months) following the onset of therapy. Three of the 7 remaining patients died of treatment complications, 2 of intestinal obstruction and 1 of disseminated histoplasmosis, within the first year of therapy and at post-mortem examination had no demonstrable tumor. Four patients are alive and free of active tumor for 10+, 10+, 32+ and 33+ months from diagnosis. Treatment complications have included hematopoietic depression, mucositis, enteritis, intestinal obstruction, excessive weight loss, malnutrition, and life-threatening infection. These results illustrate limitations in current combined modality therapy o...Continue Reading

References

Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·J L RansomC B Pratt
Jan 1, 1976·International Journal of Radiation Oncology, Biology, Physics·B JerebM Tefft
Feb 1, 1977·The American Journal of Medicine·D D Von HoffF M Muggia
Feb 1, 1977·Cancer·W LawrenceT E Moon
Oct 1, 1977·The Journal of Urology·J T CurnesH O Hustu
Jun 1, 1976·The Journal of Urology·P C RogersD M Komp
Nov 1, 1975·The British Journal of Radiology·D R BurholtS Lesher
Jan 1, 1975·Medical and Pediatric Oncology·J A OrtegaM R Karon
Dec 1, 1973·Cancer·C P HoltonB E Favara
Aug 1, 1973·Cancer·E A LefrakJ A Gottlieb
Apr 1, 1973·American Journal of Surgery·N JaffeJ E Murray
Jan 1, 1974·Seminars in Roentgenology·B Roswit
Jan 1, 1974·Seminars in Roentgenology·P Rubin
May 1, 1969·The Journal of Pediatrics·C B Pratt

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Citations

May 9, 2002·Medicine·Harrys A TorresDimitrios P Kontoyiannis
Jan 16, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·E C C CastroS Ranganathan
May 16, 2007·Journal of Pediatric Surgery·Tuan H PhamChristopher Moir
Oct 15, 1987·Cancer·J J Mazeron, H D Suit
Jan 1, 1982·Langenbecks Archiv für Chirurgie·M BolkeniusU Schütze

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