Retroperitoneal solitary fibrous tumor: surgery as first line therapy

Clinical Sarcoma Research
Rahul RajeevKiran K Turaga

Abstract

Solitary fibrous tumors (SFT) of the retroperitoneum are rare spindle cell neoplasms, with a paucity of data on treatment outcomes. We hypothesized that surgical excision offered acceptable outcomes in SFTs. The National Cancer Database (NCDB) was used to identify patients with SFT from 2004 to 2011. Primary outcome measures were 30 day mortality and overall survival. Descriptive analyses were performed. Furthermore, a systematic review of published literature was conducted after creating a pre-specified search strategy. Of 51 patients in the NCDB, 58.8 % (n = 30) were males, with a median age 60 years (IQR 49-72 years). Median tumor size was 16 cm (IQR 11-21 cm). Surgical resection was performed in 92.2 % (n = 47) with 63.8 % (n = 30) having a margin negative resection. Peri-operative mortality was 2.1 % (n = 1). Of survival outcomes available for 18 patients, the median OS was 51.1 months. From the systematic review, we identified 8 studies, with 24 patients. Median age and tumor size was similar to the NCDB [47.5 years (IQR 39-66.5 years), 12 cm (IQR 7-17 cm)]. Majority [91.7 % (n = 22)] underwent surgical excision alone while one received adjuvant chemotherapy and none received radiation. After median follow up of 54 months...Continue Reading

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Citations

Feb 6, 2017·Journal of Pathology and Translational Medicine·Jeong-Hwa KwonKyung-Ja Cho
Oct 2, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khalid Al-DasuqiMahan Mathur
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Mar 7, 2020·International Journal of Clinical Oncology·Peng LuoChunmeng Wang
Feb 9, 2021·Annals of Medicine and Surgery·Sana ShahidSummaya Saeed
May 3, 2021·Echocardiography·Ali SheikhyMasih Tajdini

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BETA
biopsies

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