PMID: 8938555Nov 1, 1996Paper

Retrorsine in breast milk influences copper handling in suckling rat pups

Journal of Hepatology
N S AstonS Tanner

Abstract

To explore the hypothesis that a second xenobiotic agent is required with excess copper to produce Indian Childhood Cirrhosis, this study investigated the effect of the pyrrolizidine alkaloid retrorsine fed to the mother during the suckling period upon the serial changes in neonatal copper status. Female Wistar rats with new-born litters were fed either a control or a retrorsine (50 mg/kg) diet. At 0, 4, 8, 11, 15, 18 and 21 days, pups from each litter were weighed, sacrificed and their livers removed for copper, DNA and metallothionein analysis. Serum samples were assayed for caeruloplasmin oxidase activity and albumin. 1) Higher than adult level of hepatic copper in normal rats which rose post-natally before declining from day 11 after birth, 2) raised hepatic copper concentrations and total copper in the retrorsine group from day 15; levels were higher than adult at birth, 3) reduced serum caeruloplasmin oxidase activity and albumin levels in retrorsine group, but both groups lower than adult, 4) lower hepatic metallothionein levels in retrorsine group, but both groups higher than adult, and 5) reduced liver DNA in the retrorsine group when expressed as total DNA and per gram of tissue. These changes were not secondary to un...Continue Reading

References

Jan 1, 1992·Annals of Tropical Paediatrics·S A BhaveM S Tanner
May 1, 1992·Gastroenterology·M AdamsonW A Gahl
Jan 1, 1991·Methods in Enzymology·A M Scheuhammer, M G Cherian
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Jan 1, 1996·Archives of Disease in Childhood·A R BavdekarM S Tanner

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Citations

Aug 31, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·W SeffnerA Hofmann
Sep 16, 1998·Natural Product Reports·J R Liddel
Jun 3, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Thaísa M SandiniHelenice de S Spinosa
Mar 14, 2002·Critical Reviews in Clinical Laboratory Sciences·M S Tanner
Jan 30, 1999·The Journal of Pathology·N S AstonS Variend

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