Abstract
To evaluate the efficacy of conservative treatment with methotrexate against placenta increta by two different routes of administration through retrospective analysis. A total of 54 women diagnosed with placenta increta after vaginal delivery were enrolled in this retrospective study. The participants accepted conservative management with methotrexate through either intravenous injection or local multi-point injection under ultrasound guidance. The treatment was considered effective if no hysterectomy was mandatory during the follow-up period. Out of the 54 cases, 21 patients were treated with methotrexate intravenously (group 1), and 33 patients received local multi-point injection to the placenta increta under ultrasound guidance (group 2). No maternal death occurred. In group 1, 10 patients expelled the placentas spontaneously, 7 patients underwent uterine curettage and 4 patients underwent hysterectomy for uncontrollable post-partum hemorrhage and infection. In group 2, 25 patients expelled placentas spontaneously and 8 patients underwent uterine curettage with no incidence of hysterectomy. The success rate in group 1 and group 2 was 17/21 and 33/33, respectively. The average time of the spontaneous placenta expulsion was 7...Continue Reading
References
Jan 1, 1986·Acta Obstetricia Et Gynecologica Scandinavica·S ArulkumaranS S Ratnam
Sep 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M H KomulainenS Saarikoski
Jul 1, 1993·Radiology·H A MittyR Gendler
Nov 14, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K Buckshee, V Dadhwal
Mar 24, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D Gupta, R Sinha
Jun 10, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·T A PanoskaltsisK D Edmonds
Sep 22, 2001·Clinical Imaging·S Z BadawyM Philadelphia
Jul 26, 2002·Fertility and Sterility·Céline PirardJacques Donnez
Jul 29, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S R AdairS Tharmaratnam
Aug 30, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R CrespoB Madani
Sep 30, 2006·Fertility and Sterility·Mark AlanisMichelle L Matthews
Jul 20, 2007·Obstetrical & Gynecological Survey·Sarah TimmermansJohannes J Duvekot
Sep 12, 2007·The Journal of Obstetrics and Gynaecology Research·Seiji SumigamaFumitaka Kikkawa
Sep 11, 2008·Archives of Gynecology and Obstetrics·Hooman Soleymani MajdLamiese Ismail
Dec 27, 2008·Fertility and Sterility·Giuseppe TrojanoEttore Cicinelli
Jul 30, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·G R DamianiG Cormio