Retrospective analysis of factors predicting end-stage renal failure or death in patients with microscopic polyangiitis with mainly renal involvement

Clinical and Experimental Nephrology
Hirohisa KawaiHirokazu Imai

Abstract

The aim of this study was to identify risk factors for end-stage renal failure (ESRF) or death in Japanese patients with microscopic polyangiitis (MPA) with renal involvement. From 54 consecutive patients with systemic vasculitis based on Watt's algorithm, we retrospectively analyzed 39 MPA patients with renal involvement, including 19 (48.7 %) with renal-limited vasculitis. Thirty-three of 39 patients (84.6 %) demonstrated rapidly progressive glomerulonephritis, and 13 (33.3 %) developed ESRF; 8 of 13 required dialysis within 1 week. Thirteen (33.3 %) died during follow-up of more than 12 months, and 7 died during the first 6 months, mainly because of opportunistic infections. Overall survival at 6 and 12 months was 79.5 and 71.1 %, respectively. Serum creatinine levels did not differ significantly between survivors and non-survivors (P = 0.092). The mean Birmingham Vasculitis Activity Score, version 3 (BVAS v.3), was 16.2 ± 6.5, with a renal subscore of over 12 points in 82.1 %, and BVAS v.3 was marginally higher in non-survivors than survivors (P = 0.045). An age- and sex-adjusted Cox proportional hazards analysis demonstrated that neither the serum creatinine level (P = 0.277) nor BVAS v.3 (P = 0.188) at initial diagnosis w...Continue Reading

References

May 1, 1997·Baillière's Clinical Rheumatology·R A LuqmaniP A Bacon
Apr 1, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony D BoothUNKNOWN Pan-Thames Renal Research Group
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sven WeidnerHarald D Rupprecht
Jun 19, 2007·Internal Medicine·Shigehiro UezonoHiroyuki Nunoi
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Jun 29, 2007·Journal of the American Society of Nephrology : JASN·Robert A F de Lind van WijngaardenUNKNOWN EUVAS
Apr 22, 2008·Clinical and Experimental Nephrology·Kensuke JohKunihiro Yamagata
Jun 21, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A WattsHiroshi Hashimoto
Dec 5, 2008·Annals of the Rheumatic Diseases·C MukhtyarR A Luqmani
Jun 18, 2009·Clinical and Experimental Nephrology·Akio KoyamaUNKNOWN Japan RPGN Registry Group
Feb 23, 2010·Nephron. Clinical Practice·Mitsuyo ItabashiKosaku Nitta
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Annelies E BerdenIngeborg M Bajema
Nov 27, 2010·Annals of the Rheumatic Diseases·Oliver FlossmannUNKNOWN European Vasculitis Study Group
Dec 17, 2010·Kidney International·Andrew S BombackGlen S Markowitz
Sep 3, 2011·Clinical Rheumatology·Mitsuyo ItabashiKosaku Nitta
Dec 17, 2011·The Journal of Rheumatology·Takashi WadaUNKNOWN Research Group of Intractable Vasculitis, Ministry of Health, Labor, and Welfare of Japan
Feb 22, 2012·Clinical and Experimental Nephrology·Kunihiro YamagataSeiichi Matsuo
Jul 5, 2012·Clinical and Experimental Nephrology·Koichi SugiyamaHirofumi Makino
Nov 28, 2012·Clinical and Experimental Nephrology·Franco FerrarioFabio Pagni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.