Retrospective analysis of suicidality in patients treated with the antidepressant desvenlafaxine

Journal of Clinical Psychopharmacology
Karen A TourianPhilip T Ninan

Abstract

The objective of this analysis was to assess the risk of increased suicidal thoughts and behavior (suicidality) with desvenlafaxine (administered as desvenlafaxine succinate) in patients with major depressive disorder (MDD). Data from 9 double-blind, 8-week studies in outpatients with MDD were analyzed retrospectively. Patients were randomly assigned to desvenlafaxine (n = 1834) or placebo (n = 1116). Adverse events (AEs) related to suicidality were identified by searching the AE database for text strings possibly related to suicidality; false positives were excluded. Narratives for each case were prepared and blinded for review. Events were classified according to the Columbia Classification Algorithm of Suicide Assessment. Odds ratios were calculated; chi tests were used to compare treatment groups. Occurrence of emerging or worsening suicidality, based on the 17-item Hamilton Rating Scale for Depression suicide item, was compared for desvenlafaxine and placebo using chi tests. In all, 17 (0.93%) of 1834 patients receiving desvenlafaxine and 8 (0.72%) of 1116 receiving placebo reported possible suicidality-related AEs. Events were relatively evenly distributed across treatment groups. One patient randomly assigned to desvenla...Continue Reading

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Jun 12, 2008·International Clinical Psychopharmacology·Daniel Z LiebermanBruno Pitrosky

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Citations

Jun 11, 2014·Expert Opinion on Pharmacotherapy·Susan G KornsteinMatthieu Boucher
Mar 13, 2014·Journal of Child and Adolescent Psychopharmacology·Robert L FindlingKaren A Tourian
Dec 1, 2017·Journal of Child and Adolescent Psychopharmacology·Karen L WeihsDalia B Wajsbrot
Mar 13, 2021·Expert Opinion on Pharmacotherapy·Trevor R Norman, James S Olver

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