PMID: 9643979Jun 27, 1998Paper

Retrospective analysis of the relationship between HUS incidence and antibiotics among patients with Escherichia coli O157 enterocolitis in the Sakai outbreak

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
S HigamiA Ookita

Abstract

An outbreak of Escherichia coli O157:H7 infection occurred in July 1996 in Sakai City. About 5000 children were infected, 122 of whom developed hemolytic uremic syndrome (HUS). In this outbreak, almost all patients were administrated some type of antibiotics. The effects of antibiotics on E. coli O157 associated hemorrhagic colitis (HC) have been controversial. In this study, we focused on the effects of antibiotics on development of HUS in the HUS in the Sakai outbreak. We retrospectively determined the antibiotics administrated within three days after the onset of HC, clinical courses, and laboratory data of 301 patients who were hospitalized and identified as Escherichia coli O157 infection by stool culture, from results of questionnaires sent by the Osaka Prefecture Medical Association to hospitals in Osaka Prefecture. The antibiotics used could be identified for 216 patients. The incidence of HUS among these patients was 11.6%. They were divided into 19 groups based on the type of antibiotics administrated. The incidence of HUS in the new quinolone (3.7%) group was low, but was high in the intravenous cephalosporin (18.2%) group. The differences in the incidence of HUS among the 19 antibiotic groups was significant (p < 0....Continue Reading

Citations

Jun 23, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Michiko OkaKenji Kuwabara
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shannon D ManningThomas S Whittam
Aug 29, 2000·Inflammatory Bowel Diseases·B Blomberg, G Järnerot
Aug 5, 2000·The Pediatric Infectious Disease Journal·C ButeauE Seidman
Oct 9, 2004·The Journal of Antimicrobial Chemotherapy·Shigeharu OieAkira Kamiya
Oct 28, 1999·FEMS Immunology and Medical Microbiology·K YoshimuraS Yoshida
Apr 11, 2008·Journal of Clinical Microbiology·James T RiordanThomas S Whittam

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