Retrospective analysis of transurethral resection, second-look resection, and long-term chemo-metaphylaxis for superficial bladder cancer: indications and efficacy of a differentiated approach

Journal of Endourology
Michael SchulzeJens Rassweiler

Abstract

Because of controversy concerning risk factors for progression, recurrence, and persistence of bladder cancer, we reviewed the data of our patients with superficial bladder tumors. Based on a differentiated approach with second-look transurethral resection (TUR) and/or intravesical metaphylaxis, we wanted to answer the following questions: Was this approach efficient? What risk factors demand a second-look TUR? Is surveillance appropriate for patients at low risk? Retrospectively we analyzed the data of 251 patients with superficial bladder cancer with a mean follow-up time of 69 (range 20 to 107) months. We focused on recurrence rates, tumor-persistence and progression, and types of adjuvant treatment. An early reintervention within 6 to 8 weeks after primary resection was defined as a second-look TUR. To judge the necessity of early reintervention and metaphylaxis, we performed a matched-pair analysis for the low-risk group. Tumor stages included T(a) (170 patients, 68%); T(1) (72 patients, 29%); carcinoma in situ (CIS) (9 patients, 4%). Grades included grade 1 (58 patients, 23%); grade 2 (117 patients, 47%); and grade 3 (76 patients, 30%). Thirty-eight (15%) tumors were already classified as recurrent. A second-look TUR was ...Continue Reading

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Citations

Aug 6, 2011·Journal of Endourology·Hans-Martin FritscheMaximilian Burger
Feb 9, 2012·BJU International·Mario RichterstetterFrens Steffen Krause
Jan 23, 2014·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Mario W KramerThomas R W Herrmann
Jan 7, 2015·Asian Journal of Surgery·Cemal KaraTurker Karabuga
Oct 31, 2013·Expert Review of Anticancer Therapy·Anna V van LingenJ Alfred Witjes
Nov 30, 2010·Expert Review of Anticancer Therapy·Rianne J M Lammers, J Alfred Witjes
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hui ZhanMing-Xia Ding

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