PMID: 15214654Jun 25, 2004Paper

Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years

Clinical Oncology : a Journal of the Royal College of Radiologists
K MalakerT Al Yafi

Abstract

The purpose of the study was to review retrospectively the role of primary radiotherapy for unresectable keloids. Kilovoltage X-rays and mega-voltage electron beams were used to irradiate large bulky unresectable keloids. A total of 3750 cGy was given in five once-weekly fractions, over a period of 5 weeks. Eighty-six keloids in 64 patients were treated between 1977 and 2002. Ninety-seven per cent of this cohort had significant regression, and 3% had partial regression 18 months after completing radiotherapy. Both acute and long-term reactions were acceptable, and so far none of the patients have been reported as having cancer of any sort. Sixty-three per cent of the patients surveyed were very happy with the outcome of their treatment. Unresectable bulky symptomatic keloids can be satisfactorily treated with hypo-fractionated radiotherapy primarily using either kilovoltage X-rays or electron beams without significant short- or long-term side-effects.

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