Retrospective Analysis on the Use of Amphotericin B Lipid Complex in Neutropenic Cancer Patients with Suspected Fungal Infections in Lebanon, a Single Center Experience and Review of International Guidelines

Frontiers in Medicine
Rima MoghniehAhmad Ibrahim

Abstract

Immunocompromised patients carry a high risk for invasive fungal disease (IFD), which is associated with high mortality. This is a retrospective chart review of a 4-year experience of amphotericin B lipid complex (ABLC) utilization for the management of suspected IFD at the Hematology/Oncology and Bone Marrow Transplantation unit at Makassed General Hospital, Beirut, Lebanon between January 2011 and December 2014. We focused on treatment strategy, response rate, and adverse drug events associated with ABLC therapy. We also reviewed ABLC indications in international guidelines beyond its Food and Drug Administration approval. A total of 89 patients received ABLC therapy for suspected fungal infection. Forty-eight percent were treated for a possible fungal infection, 19% for a problable fungal infection, 12% based on hospital guidelines, and 20% based on treating physician's recommendations. The overall response rate was 71%. Nephrotoxicity occurred in 24% of patients and serum creatinine improved in 10% of these patients. Moderate hypokalemia was observed in 61% of the patients and severe hypokalemia in 10% but was corrected in both cases. Hepatotoxicity was observed in 12% of the patients throughout ABLC therapy. Infusion-relat...Continue Reading

References

Jun 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T J WalshE J Anaissie
Oct 14, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Wong-BeringerB J Guglielmo
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W E Dismukes
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R WingardUNKNOWN L Amph/ABLC Collaborative Study Group
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M TiphineR Herbrecht
Jan 22, 2002·The Journal of Antimicrobial Chemotherapy·Bertrand Dupont
Dec 11, 2002·Expert Opinion on Therapeutic Targets·Carmela Giglione, Thierry Meinnel
Jul 18, 2003·Clinical Therapeutics·Jane P BarrettUNKNOWN Amphotericin B Systematic Review Study Group
Sep 10, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J-M AguadoUNKNOWN Grupo de Farmacovigilancia de Abelcet
Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara D Alexander, John R Wingard
Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshUNKNOWN Infectious Diseases Society of America
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben De PauwUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Oct 24, 2009·Current Medical Research and Opinion·Patrick Chu, Shalal Sadullah
Dec 2, 2009·Expert Opinion on Drug Safety·Charles CraddockJohn-Liu Yin
Jul 28, 2010·Bone Marrow Transplantation·J MaertensUNKNOWN Third European Conference on Infections in Leukemia
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
Jan 4, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A J UllmannUNKNOWN ESCMID Fungal Infection Study Group
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupUNKNOWN European Confederation of Medical Mycology
Jan 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C Arendrup
Feb 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·O A CornelyG Petrikkos
Feb 20, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A M TortoranoC Lass-Flörl

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Citations

Apr 27, 2021·Expert Opinion on Drug Safety·Athanasios TragiannidisAndreas H Groll

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Methods Mentioned

BETA
X-ray
bronchoalveolar lavage
biopsies

Software Mentioned

SPSS

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