Abstract
We estimated the accuracy of a modified commonly used set of clinical diagnostic criteria for the diagnosis of multiple system atrophy (MSA) by retrospectively applying the criteria to the features recorded by six neurologists who had evaluated 105 autopsy-confirmed cases (16 MSA and 89 non-MSA disorders). Cases were abstracted from the records of the patients' first visit to an academic center, and were presented as clinical vignettes to six neurologists, each of whom recorded the main clinical features of the presented clinical vignette on a standardized form. Sensitivity and positive predictive values were chosen as validity outcome measures and were calculated by comparing the applied diagnostic criteria to the neuropathologic information. Of note, most MSA patients in this study (mainly those with Shy-Drager type) had not received levodopa therapy since the primary neurologists often had not perceived a need to administer this treatment. The validity of the retrospectively applied criteria for the diagnosis of possible MSA (sensitivity: median, 53%, range, 50-69%; positive predictive value: 30%, 28-39%) and probable MSA (sensitivity: 44%, 31-60%; positive predictive value: 68%, 54-80%) at the first visit was suboptimal. Th...Continue Reading
Citations
Jun 10, 2009·Archives of Neurology·Axel LippPhillip A Low
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·F TisonF Yeklef
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·François TisonGregor K Wenning
Jan 27, 2004·NeuroImage·Thomas EckertMircea Ariel Schoenfeld
Feb 28, 2001·Neuroscience·R WaldnerG K Wenning
Jan 30, 2004·Lancet Neurology·Gregor K WenningWerner Poewe
Jul 12, 2008·The Neurologist·Roongroj Bhidayasiri, Helen Ling
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Eckert, David Eidelberg
Nov 9, 2001·CNS Drugs·G K Wenning, S Braune
May 2, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Irene LitvanUNKNOWN Movement Disorders Society Scientific Issues Committee
May 24, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kenichi OishiFumio Kanda
Jan 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas EckertDavid Eidelberg
Nov 20, 2004·The Psychiatric Clinics of North America·Edward C Lauterbach
Jun 16, 2005·NeuroImage·Thomas EckertD Eidelberg
Nov 18, 2008·Neurobiology of Disease·Kathleen L Poston, David Eidelberg
Nov 11, 1999·Current Opinion in Neurology·I Litvan
Nov 9, 2020·Aging·Fan-Shuen TsengEng-King Tan