Retrospective case-control study of necrotizing enterocolitis and packed red blood cell transfusions in very low birth weight infants

Journal of Neonatal-perinatal Medicine
C S CrabtreeD H Adamkin

Abstract

The study objective was to explore the relationship between necrotizing enterocolitis (NEC) and packed red blood cell (pRBC) transfusion in very low birth weight (VLBW) neonates (<1500 g). A six-year retrospective chart review of VLBW infants with NEC (Bell's Stage > II) and a pRBC transfusion within 48 hours of diagnosis. Prenatal data, postnatal course, transfusion history, and NEC outcomes were reviewed. The transfusion associated necrotizing enterocolitis (TANEC) cases were matched with controls (1:2) who were transfused but did not develop NEC as to proximity of birth date, gestational age, and receipt of transfusion. Of 1139 VLBW admissions, there were 73 cases of NEC and 30 cases of TANEC (annual NEC rate 6.4%). TANEC cases were matched with 60 controls who were transfused but never developed NEC. Neonatal profiles were similar between all 3 groups, except for a higher proportion of infants <10th percentile in the non-TANEC group. Days of antibiotics and frequency of patient ductus arteriosus (PDA) ligation were lower in controls compared to NEC cases. Lower feeding rate at diagnosis of NEC/match were more common in control infants compared to TANEC infants. However, feeding abstinence rates were similar between the two ...Continue Reading

References

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Citations

Feb 6, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dan ArbellSaul Yedgar
May 4, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Emma Killion
Mar 7, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Leslie A ParkerMarina Magalhães
May 23, 2020·Clinics in Perinatology·Allison Thomas RoseRavi Mangal Patel

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