Retrospective Claims Analysis Indirectly Comparing Medication Adherence and Persistence Between Intravenous Biologics and Oral Small-Molecule Therapies in Inflammatory Bowel Diseases

Advances in Therapy
Kellyn MoranS Kane

Abstract

Patients' adherence to and persistence on treatment for inflammatory bowel disease (IBD) can vary, depending on type and distribution of disease and treatment modality. We aim to identify differences in adherence and persistence with treatments with different administration routes (intravenous vs oral) in IBD. A retrospective cohort analysis of a claims database of adult patients diagnosed with IBD or rheumatoid arthritis (RA) who began treatment with vedolizumab, tofacitinib, or infliximab from January 2015 through December 2015. Adherence evaluated by proportion of days covered (PDC) and cumulative days with gaps at least 20% beyond expected interval (CG20) using multivariable generalized linear equation models. Persistence assessed as time to treatment discontinuation over 12 months of follow-up using Kaplan-Meier estimates and Cox proportional hazards models; proportion of persistent patients determined via multivariable logistic regression. Indirect comparisons across disease states adjusted using infliximab data. After indirect adjustment by disease, mean PDC difference was significantly higher (difference of 4.7%; P = 0.0376) and mean CG20 was lower (difference of 15 days; P = 0.0646) but not statistically significant in...Continue Reading

References

Sep 15, 2009·World Journal of Gastroenterology : WJG·Peter Laszlo Lakatos
Dec 10, 2009·The American Journal of Gastroenterology·C A JacksonRob Horne
Feb 2, 2011·The Journal of Rheumatology. Supplement·Brian BresslerAlessandro Sette
Nov 9, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Pengxiang LiJalpa A Doshi
Mar 23, 2013·Inflammatory Bowel Diseases·Anthony LopezLaurent Peyrin-Biroulet
Jun 6, 2013·Patient Preference and Adherence·Kunal SrivastavaAndrew M Peterson
Aug 24, 2013·The New England Journal of Medicine·William J SandbornUNKNOWN GEMINI 2 Study Group
Sep 13, 2014·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Takuma Harada, Hiroyuki Nakamura
Sep 27, 2014·ClinicoEconomics and Outcomes Research : CEOR·Luca Degli EspostiStefano Buda
Mar 17, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Valerie L MorrisonDyfrig A Hughes
Sep 12, 2015·Inflammatory Bowel Diseases·Margot L Herman, Sunanda V Kane
Sep 28, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Piia K RannanheimoMaarit Jaana Korhonen
Dec 19, 2015·Journal of Crohn's & Colitis·Emily E VivioMatthew A Ciorba
Nov 16, 2016·Patient Preference and Adherence·Rieke AltenHans-Dieter Nolting
May 4, 2017·The New England Journal of Medicine·William J SandbornUNKNOWN OCTAVE Induction 1, OCTAVE Induction 2, and OCTAVE Sustain Investigators
Apr 19, 2018·Inflammatory Bowel Diseases·Brian J WentworthBrian W Behm

❮ Previous
Next ❯

Citations

Apr 15, 2020·Journal of Pediatric Gastroenterology and Nutrition·David H BarkerNeal Leleiko
Dec 28, 2019·Journal of Crohn's & Colitis·Marc Ferrante, João Sabino
May 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·David H BarkerNeal S Leleiko
Dec 10, 2020·Inflammatory Bowel Diseases·Elleni J Pippis, Bruce R Yacyshyn

❮ Previous
Next ❯

Software Mentioned

GEMINI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.