Retrospective cohort study comparing the adverse reactions and efficacy of intravenous iron polymaltose with ferric carboxymaltose for iron deficiency anemia

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Christine E GilmartinLaura Leung

Abstract

To examine the adverse drug reactions (ADRs) and the efficacy of intravenous iron polymaltose and ferric carboxymaltose (FCM) among gynecology/obstetric patients with anemia. The present retrospective observational study examined data from anemic obstetrics and gynecology patients who received either iron polymaltose or FCM between January 1, 2011, and April 30, 2015, at The Royal Women's Hospital, Victoria, Australia. Patient demographic data, dosage, ADR documentation, and hemoglobin levels were collected from medical records and compared. The study included 221 patients; 111 and 110 received iron polymaltose and FCM, respectively. ADRs were documented for 18 (16.2%) patients in the iron polymaltose group and 2 (1.8%) in the FCM group (P<0.001), with no incidences of anaphylaxis. Both formulations achieved increased hemoglobin levels within 12 weeks (P<0.001 for both). Mean hemoglobin level increases were similar in both groups among non-pregnant patients (P=0.186), but were greater in the iron polymaltose cohort among pregnant patients (P=0.005). FCM dose compliance was suboptimal, with 8 of 57 (14%) patients who required second visits for doses greater than 1000 mg returning for the infusion. FCM was associated with a lower...Continue Reading

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Citations

Mar 19, 2019·Hospital Practice·Adrian Y S Lee, Selina H P Leung
Jun 21, 2019·Current Molecular Biology Reports·Jonathan A Wheeler, Erica L Clinkenbeard
Dec 24, 2020·Internal Medicine Journal·Syarihan KarimMurray L Barclay
Sep 10, 2021·International Journal of Clinical Pharmacy·Chuin Khai LimCorinne Mirkazemi
Nov 11, 2021·Current Osteoporosis Reports·Petra Simic, Jodie L Babitt

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