Abstract
To examine the adverse drug reactions (ADRs) and the efficacy of intravenous iron polymaltose and ferric carboxymaltose (FCM) among gynecology/obstetric patients with anemia. The present retrospective observational study examined data from anemic obstetrics and gynecology patients who received either iron polymaltose or FCM between January 1, 2011, and April 30, 2015, at The Royal Women's Hospital, Victoria, Australia. Patient demographic data, dosage, ADR documentation, and hemoglobin levels were collected from medical records and compared. The study included 221 patients; 111 and 110 received iron polymaltose and FCM, respectively. ADRs were documented for 18 (16.2%) patients in the iron polymaltose group and 2 (1.8%) in the FCM group (P<0.001), with no incidences of anaphylaxis. Both formulations achieved increased hemoglobin levels within 12 weeks (P<0.001 for both). Mean hemoglobin level increases were similar in both groups among non-pregnant patients (P=0.186), but were greater in the iron polymaltose cohort among pregnant patients (P=0.005). FCM dose compliance was suboptimal, with 8 of 57 (14%) patients who required second visits for doses greater than 1000 mg returning for the infusion. FCM was associated with a lower...Continue Reading
References
May 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C GranollerasS Shaldon
Mar 21, 1998·European Journal of Haematology·K SinghP Kuperan
Jan 27, 2005·The Journal of Nutrition·John L BeardMark Tomlinson
Sep 9, 2006·Internal Medicine Journal·E NewnhamP R Gibson
Oct 7, 2008·Blood Reviews·Mary Ann KnovichFrank M Torti
May 1, 2009·Internal Medicine Journal·M L Haines, P R Gibson
Jun 16, 2010·Journal of Internal Medicine·A KhalafallahJ E J Rasko
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Rodolfo Delfini Cançado, Manuel Muñoz
Mar 29, 2014·BMC Pregnancy and Childbirth·Bernd FroesslerGustaaf Dekker
Nov 25, 2014·Haematologica·David RamptonGuenter Weiss
Jun 11, 2015·Medicine·Ole Haagen NielsenGünter Weiss
Dec 17, 2015·Revista brasileira de hematologia e hemoterapia·João Ricardo Friedrisch, Rodolfo Delfini Cançado
Jun 10, 2016·Journal of Perinatal Medicine·Christian BreymannUNKNOWN FER-ASAP investigators
Sep 1, 2012·Obstetric Medicine·B MyersJ Moore
Jun 14, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Alaa QassimLuke E Grzeskowiak
Citations
Mar 19, 2019·Hospital Practice·Adrian Y S Lee, Selina H P Leung
Jun 21, 2019·Current Molecular Biology Reports·Jonathan A Wheeler, Erica L Clinkenbeard
Dec 24, 2020·Internal Medicine Journal·Syarihan KarimMurray L Barclay
Sep 10, 2021·International Journal of Clinical Pharmacy·Chuin Khai LimCorinne Mirkazemi
Nov 11, 2021·Current Osteoporosis Reports·Petra Simic, Jodie L Babitt