Retrospective cohort study of liver transplantation in the United Kingdom between 1994 and 2010: the impact of hepatitis C infection

Public Health
O EdeghereM E Ramsay

Abstract

Liver transplantation is an important and established treatment option for chronic hepatitis C virus (HCV) related end-stage liver disease (HCV-related ESLD). This study describes trends in elective liver transplantation among persons with HCV-related ESLD. Retrospective cohort. Analyses of United Kingdom (UK) Transplant Registry data for the period 1994 to 2010, with follow-up information extending to 2011. Annual registrations for liver transplantation increased linearly and alcoholic liver cirrhosis (2075, 24%) and HCV-related ESLD (1213, 14%) were the most common indications. HCV-related ESLD patients were mainly aged 40-49 years (32%) and 50-59 years (43%); males (76%); and of white ethnicity (74%). Overall, 75% (956/1213) received a liver transplant with a linear increase over the period (OR 1.11, 95% CI 1.08, 1.13). Pre transplant mortality was unchanged (adjusted OR 1.0, 95% CI 0.96, 1.05) and post-transplant mortality decreased in both HCV-related (adjusted OR 0.77, 95% CI 0.68, 0.88) and non-HCV-related ESLD (adjusted OR 0.82, 95% CI 0.75, 0.89) patients. The increase in demand for and receipt of liver transplants among persons with HCV-related ESLD requires coordinated efforts to increase not only organ donation, but...Continue Reading

References

Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K H BökerM P Manns
Jan 27, 2004·Transplantation·Ulf P NeumannPeter Neuhaus
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David A StellDouglas Thorburn
Apr 15, 2006·International Journal of Medical Sciences·Theodore Sy, M Mazen Jamal
Apr 13, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E A PomfretR M Merion
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Paul J ThuluvathHwan Y Yoo
Jul 26, 2007·Journal of Viral Hepatitis·M J SweetingM E Ramsay
Sep 19, 2007·Transplantation·Jan H P van der MeulenUNKNOWN UK and Ireland Liver Transplant Audit
Nov 21, 2007·Journal of Hepatology·Juan I EstebanJosep Quer
Jan 23, 2008·Journal of Viral Hepatitis·A G MannM E Ramsay
Jan 17, 2009·BMJ : British Medical Journal·Amber RithaliaAmanda Sowden
Feb 7, 2009·European Journal of Public Health·Gaby SroczynskiUwe Siebert
Jun 24, 2009·American Journal of Epidemiology·Michael J SweetingDaniela De Angelis
Jan 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·UNKNOWN European Association of the Study of the Liver
Apr 5, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natasha K MartinMatthew Hickman

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Citations

Jan 8, 2016·Journal of Hepatology·Philip N OkaforJayant A Talwalkar
Dec 31, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Scott A McDonaldSharon J Hutchinson

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