Retrospective cohort study of statin therapy effect on resected colorectal liver metastases

World Journal of Gastrointestinal Surgery
Edward AlabrabaNottingham Hpb Surgery Group

Abstract

Above and beyond their role in cardiovascular risk reduction, statins appear to have a chemopreventive role in some gastro-intestinal cancers. In the quest for new chemopreventive agents, some existing established drugs such as statins have shown potential for re-purposing as chemoprevention. Probing existing drugs, whose pharmacodynamics are familiar, for novel beneficial effects offers a more cost-effective and less time-consuming strategy than establishing brand new drugs whose pharmacodynamic profile is unfamiliar. Observational studies show statins decrease the risk of developing colorectal cancer but there are no published studies exploring the potential impact of statins on carcinogenesis in colorectal liver metastases (CRLM). To evaluate impact of statins on outcomes of CRLM resection, and secondarily to assess if statins influence CRLM histo-pathology. We conducted a retrospective cohort study of patients operated for CRLM over a 13-year period from 2005 to 2017. Patients were identified from a prospective database maintained in our Tertiary care hospital. All 586 patients included the study had undergone resection of CRLM following discussion at multidisclipinary team meeting, some patients requiring neoadjuvant chemo...Continue Reading

References

Apr 26, 2002·The British Journal of Surgery·D J Hole, C S McArdle
Oct 13, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Adam, E Vinet
May 27, 2005·The New England Journal of Medicine·Jenny N PoynterGad Rennert
May 12, 2007·Surgical Oncology·Donald C McMillan, Colin S McArdle
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James S TomlinsonMichael D'Angelica
Oct 14, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C P NealD P Berry
May 25, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dhanny GomezK Raj Prasad
Jul 28, 2010·Gut·Marc BardouMyriam Martel
Jan 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoine BrouquetJean-Nicolas Vauthey
Mar 13, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dhanwant GomezIain C Cameron
Jul 6, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Matthew G WiggansDavid A Stell
Aug 6, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chris R CardwellLiam J Murray
Sep 16, 2014·Critical Reviews in Oncology/hematology·Peter KubatkaBeata Mladosievicova
May 20, 2015·Annals of Surgical Oncology·Jannemarie A M de RidderIris D Nagtegaal
Apr 7, 2016·OncoTargets and Therapy·Yang MengJia Wang
May 14, 2016·International Journal of Cancer. Journal International Du Cancer·Sashidhar ManthravadiSheshadri Madhusudhana
Mar 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonDeborah Freedman-Cass
May 18, 2017·Gastroenterology·Philip W VoorneveldGerrit Jan Liefers
Jun 14, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A E VallanceK Walker

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Citations

Aug 10, 2021·Frontiers in Oncology·Preeti Kanikarla MarieDavid George Menter

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