Retrospective cohort study of surgical staging for ovarian low malignant potential tumors

American Journal of Obstetrics and Gynecology
Shana N WingoJohn O Schorge

Abstract

The purpose of this study was to determine the benefit of surgically staging ovarian low malignant potential tumors. This was a retrospective cohort study of all ovarian low malignant potential tumors that were diagnosed by frozen section or final pathologic review from 2003 to 2005. Twenty-two of 32 patients (69%) were staged surgically. Sixteen low malignant potential tumors were stage I by final pathologic review, and 4 tumors were upstaged to stage II-III disease. Two other patients had early invasive ovarian carcinoma, despite a frozen section that suggested low malignant potential; 1 patient received adjuvant chemotherapy. The tumors of 10 women (31%) were unstaged. Frozen section suspicion of low malignant potential (P = .003) and surgery by a gynecologic oncologist (P < .001) correlated with staging. Preoperative CA-125, intraoperative blood loss, and postoperative hospitalization were increased in patients with staged disease (each P < .05). Two women who underwent fertility-sparing surgery experienced a recurrence in the contralateral ovary. Surgical staging of ovarian low malignant potential tumors has limited value for most patients, unless invasive carcinoma is diagnosed by final pathologic review.

References

Jun 25, 2002·Gynecologic Oncology·Cornelia Liu TrimbleEdward L Trimble
Oct 18, 2002·Obstetrics and Gynecology·William E WinterG Larry Maxwell
Aug 5, 2004·Obstetrics and Gynecology·Gautam G RaoJohn O Schorge

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Citations

Jan 7, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Seung-Hyuk ShimSun Joo Lee
Jan 17, 2012·Hematology/oncology Clinics of North America·John O SchorgeDennis S Chi
Mar 18, 2011·American Journal of Obstetrics and Gynecology·Ramez N EskanderRobert E Bristow
May 2, 2016·American Journal of Obstetrics and Gynecology·Sherif A M ShazlyAbimbola O Famuyide
Mar 2, 2016·The Cochrane Database of Systematic Reviews·Nithya D G RatnaveluRaj Naik
Oct 27, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·James MayRachel Louise O'Donnell
Nov 10, 2007·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Andreas Obermair, Sonja Hiebl

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