Retrospective detection and phylogenetic analysis of swine acute diarrhoea syndrome coronavirus in pigs in southern China

Transboundary and Emerging Diseases
Ling ZhouJing-Yun Ma

Abstract

Swine acute diarrhoea syndrome coronavirus (SADS-CoV), a novel coronavirus, was first discovered in southern China in January 2017 and caused a large scale outbreak of fatal diarrheal disease in piglets. Here, we conducted a retrospective investigation of 236 samples from 45 swine farms with a clinical history of diarrheal disease to evaluate the emergence and the distribution of SADS-CoV in pigs in China. Our results suggest that SADS-CoV has emerged in China at least since August 2016. Meanwhile, we detected a prevalence of SADS-CoV (43.53%), porcine deltacoronavirus (8.83%), porcine epidemic diarrhoea virus (PEDV) (78.25%), rotavirus (21.77%), and transmissible gastroenteritis virus (0%), and we also found the co-infection of SADS-CoV and PEDV occurred most frequently with the rate of 17.65%. We screened and obtained two new complete genomes, five N and five S genes of SADS-CoV. Phylogenetic analysis based on these sequences revealed that all SADS-CoV sequences in this study clustered with previously reported SADS-CoV strains to form a well defined branch that grouped with the bat coronavirus HKU2 strains. This study is the first retrospective investigation for SADS-CoV and provides the epidemiological information of this ne...Continue Reading

References

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Citations

Jun 18, 2019·Transboundary and Emerging Diseases·Ling ZhouJing Y Ma
Sep 11, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laura K BorkenhagenGregory C Gray
Dec 24, 2018·Porcine Health Management·Korakrit PoonsukLuis Giménez-Lirola
Jan 26, 2021·Archives of Virology·Wenwen XiaoLiurong Fang
Mar 17, 2021·Virologica Sinica·Hanna Turlewicz-Podbielska, Małgorzata Pomorska-Mól
Sep 26, 2020·Veterinary Medicine and Science·Médiha Khamassi KhbouM'hammed Benzarti
Jul 13, 2021·Veterinary Research Communications·Qiang Liu, Huai-Yu Wang
Aug 28, 2021·Life·Fabio ScarpaMassimo Ciccozzi
Sep 4, 2021·Analytical Biochemistry·Hoda IlkhaniSiamak Farhad

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Datasets Mentioned

BETA
MG605090
MG605091
MG775253
MG775250
MG775252
MF167434
MF370205

Methods Mentioned

BETA
PCR

Software Mentioned

DNAStar
MEGA

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