Retrospective Evaluation of Cyclosporine in the Treatment of Chronic Hepatitis in Dogs: 2010-2017

BioRxiv : the Preprint Server for Biology
Yoko AmbrosiniCynthia R L Webster

Abstract

Background: Idiopathic chronic hepatitis (CH) in dogs is a prevalent hepatic disorder. The etiology is poorly understood; however, there is evidence to support an immune-mediated pathogenesis. No literature exists investigating the efficacy of cyclosporine (CsA) therapy for CH in dogs. Objectives: To retrospectively evaluate the efficacy and adverse side effects of CsA in the treatment of CH in dogs, and to identify factors that impact response to CsA therapy. Animals: 48 client-owned dogs diagnosed with CH treated with CsA for at least 2 weeks. Methods: Retrospective review of medical records between the years 2010-2017. Results: Twenty-two breeds of dogs were included of which 54% were spayed females, 42% neutered males and 4% intact males. Median age was 8.5 years (range, 0.7-14 years). Complete remission (normalization of alanine aminotransferase [ALT]) in response to CsA was attained in 79% of dogs (38/48). Median dose of CsA at the time of remission was 7.9 mg/kg/day (range, 2.5-12.7 mg/kg/day) and median time to remission was 2.5 months (range, 0.75-18 months). None of the factors evaluated including clinical score, presence of ascites, hypoalbuminemia, hyperbilirubinemia, prolonged coagulation times, dose, or duration o...Continue Reading

Related Concepts

Alanine Transaminase
Breeding
Cyclosporine
Canis familiaris
Gingival Hyperplasia
Hepatitis, Chronic
Hyperbilirubinemia
Literature
Liver Diseases
Retrospective Studies

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