Retrospective evaluation of decision-making for pancreatic stereotactic MR-guided adaptive radiotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Marguerite TyranPercy Lee

Abstract

Stereotactic-magnetic-resonance-guided-online-adaptive-radiotherapy (SMART) is a promising tool for pancreas stereotactic-body-radiotherapy. Our online-adaptive-radiotherapy (On-ART) process relies on daily image overview by the managing radiation-oncologist, who determines the need for creating a predicted plan if significant interfractional anatomical changes are noted. Predicted plans are achieved through applying the baseline plan on deformed and manually adjusted contours based on daily imaging. If the dose to the target volume or organs-at-risk (OARs) violate constraints, an adapted plan is generated and delivered for treatment. In-depth review of daily images and deformed contours is limited by time and inter-observer variations. This study evaluates the reliability of our On-ART decision-making process. All fractions retrospectively underwent a predicted plan for off-line decision-making to adapt (Off-ART). Decisions to adapt were compared using On-ART and Off-ART approaches. Thirty-five sets of daily images were analyzed from seven patients who underwent five fractions of SMART. Each OAR was fully re-contoured off-line by the same physician for each fraction. Off-ART decision was re-evaluated for each fraction. N = 14/...Continue Reading

Citations

Aug 21, 2019·The British Journal of Radiology·Ann RaldowTheodore Hong
Dec 7, 2019·Journal of Applied Clinical Medical Physics·Richard Y WuSteven J Frank
Oct 28, 2019·Journal of Medical Imaging and Radiation Oncology·Stephen ChinAnanya Choudhury
Dec 15, 2020·Bulletin du cancer·Agnès TalletPierre Fau
Jan 21, 2021·International Journal of Radiation Oncology, Biology, Physics·Carri K Glide-HurstEvan Wuthrick
Oct 16, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·William A HallUNKNOWN MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium
Mar 26, 2021·Frontiers in Oncology·Daniela Thorwarth, Daniel A Low
Apr 20, 2021·Frontiers in Oncology·Luca BoldriniLaura Dawson
Apr 4, 2021·International Journal of Radiation Oncology, Biology, Physics·Alba Magallon-BaroMischa S Hoogeman
Sep 22, 2021·Radiation Oncology·Francesco CucciaStefanie Corradini

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